Jove
Visualize
Contact Us

Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

2.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.9K
Bone Disorders01:29

Bone Disorders

3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
  1. Home
  3. The Effects Of Resveratrol In Animal Models Of Primary Osteoporosis: A Systematic Review And Meta-analysis.
  1. Home
  3. The Effects Of Resveratrol In Animal Models Of Primary Osteoporosis: A Systematic Review And Meta-analysis.

Related Experiment Video

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

8.2K

The effects of resveratrol in animal models of primary osteoporosis: a systematic review and meta-analysis.

Rongxian An1, Qian Luo2, Lei Li1

  • 1Yanbian University Hospital, Yanji, China.

Journal of Orthopaedic Surgery and Research
|February 13, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Resveratrol (Res) supplementation significantly improves bone mineral density and microstructural indices in animal models of primary osteoporosis. This meta-analysis suggests Res offers a protective effect for osteoporosis treatment.

Keywords:
Animal modelsPrimary osteoporosisResveratrol

More Related Videos

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
04:23

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

Published on: February 21, 2025

315
A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

11.7K

Related Experiment Videos

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

8.2K
The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
04:23

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

Published on: February 21, 2025

315
A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

11.7K

Area of Science:

  • Biomedical Science
  • Pharmacology
  • Osteology

Background:

  • Limited evidence exists on resveratrol's effects on primary osteoporosis (OP).
  • This meta-analysis evaluates resveratrol's role in animal models of primary OP.

Approach:

  • Comprehensive search of PubMed, Cochrane Library, Web of Science, and Embase databases up to August 2023.
  • Risk of bias assessed using the SYRCLE RoB tool.
  • Random- or fixed-effects models employed for meta-analysis.

Key Points:

  • Resveratrol significantly increased bone mineral density (BMD), bone volume/total volume (BV/TV), trabecular thickness (Tb.Th), and trabecular number (Tb.N).
  • Resveratrol markedly decreased trabecular separation (Tb.Sp), alkaline phosphatase (ALP), tartrate-resistant acid phosphatase 5b (TRAP5b), and type I collagen C-telopeptide (CTX-1).
  • Resveratrol increased osteoprotegerin (OPG) levels.

    • Conclusions:

    • Resveratrol enhances BMD and improves trabecular microstructure in primary osteoporosis models.
    • Resveratrol positively modulates serum bone turnover markers (BTMs).
    • Resveratrol demonstrates a protective effect, providing an experimental reference for its use in primary osteoporosis treatment.