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Published on: February 15, 2019
[Skin fibrosis : Novel insights in pathophysiology and treatment]
Sebastian Willenborg1, Sabrina Satzinger1, Sabine A Eming2,3,4,5
1Klinik und Poliklinik für Dermatologie und Venerologie, Uniklinik Köln, Kerpener Str. 62, 50937, Köln, Deutschland.
Abstract:
The pathogenesis of fibrosing alterations in the skin and other organ systems is not yet sufficiently understood and current therapeutic options are limited. Fibrosing diseases of the skin lead to a loss of function, which can subsequently be accompanied by serious impairments in quality of life, increased morbidity and ultimately increased mortality. There are currently only a few pharmacological and therapeutic approaches approved to prevent or ameliorate fibrosing diseases. Furthermore, tissue-specific versus common, non-organ-specific pathophysiological cellular and molecular mechanisms are not resolved. The development of new, cause-based and therefore likely more efficient therapeutic approaches is urgently needed. This represents a major challenge, but also opens up the opportunity for special contributions to improve this medically unsolved problem. Here we present important findings from recent years with a focus on the role of the immune response in fibrogenesis.
Insights
Understanding fibrosing diseases, like those affecting skin, is crucial as current treatments are limited. This research highlights the immune response
Area of Science:
- Dermatology and Immunology
- Molecular and Cellular Biology
- Pathophysiology of Fibrosis
Context:
- Fibrosing diseases affect multiple organ systems, leading to significant functional loss, reduced quality of life, and increased mortality.
- Current therapeutic strategies for fibrotic conditions are limited, with a lack of understanding regarding tissue-specific and common pathogenic mechanisms.
- The unmet medical need for effective treatments for fibrotic diseases necessitates novel, cause-based therapeutic approaches.
Purpose:
- To review recent findings on the role of the immune response in fibrogenesis.
- To elucidate the complex cellular and molecular mechanisms underlying fibrotic alterations.
- To identify potential targets for novel therapeutic interventions in fibrotic diseases.
Summary:
- This review focuses on the critical involvement of the immune system in the development of fibrosis.
- It synthesizes recent research on the pathophysiology of fibrotic diseases across various organs.
- Key findings regarding the immune response's contribution to fibrogenesis are presented.
Impact:
- Provides a foundation for developing more effective, targeted therapies for fibrotic conditions.
- Contributes to a deeper understanding of the immune system's role in disease pathogenesis.
- Offers potential avenues for improving patient outcomes and reducing disease-related morbidity and mortality.
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