Free will: An Example of the Dopaminergic System

Neuroscience has convinced people that much of their behavior is determined by causes unknown to them and beyond their control. However, are advances in neuroscience truly a prerequisite for such beliefs? Robert Kane's theory of ultimate responsibility is libertarian theory. Its innovative nature makes it possible to discuss the neurophysiological basis of its postulates. Using the functions of the midbrain dopaminergic system as an example, this article provides an overview of this neurophysiological basis. According to Kane, if we are to be ultimately responsible for our wills as well as for our actions, some actions in our lives must lack sufficient motives and causes. These are self-forming actions. Dopamine is hypothesized to mediate self-forming action execution. Dopamine not only mediates action but also ensures synaptic plasticity in the brain, that is, learning from action; hence, dopamine changes the acting individual and provides the formation of our own wills. The basal ganglia, which are the main target of dopamine in the brain, act through parallel pathways and are involved in decision-making processes. Dopamine is also involved in the regulation of the neurodynamical properties of prefrontal cortex networks with random spiking noise. It can be assumed that the activity of the dopaminergic system is closely related to the physiological basis of free will.