Clinicopathological and cellular senescence biomarkers in chronic stalled wounds
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Cellular senescence, a state of cell cycle arrest, contributes to chronic wound healing delays in humans. Increased expression of cellular senescence markers like CDKN1A predicts longer healing times, particularly in diabetic wounds.
Area Of Science
- Wound healing research
- Cellular senescence
- Diabetic complications
Background
- Chronic wounds exhibit increased cellular senescence, a state of irreversible cell cycle arrest.
- The role of senescent cells in human chronic wound chronicity remains unclear.
- Cellular senescence is characterized by resistance to apoptosis and a secretory phenotype.
Purpose Of The Study
- To assess the role of clinicopathological characteristics in chronic wound healing.
- To evaluate the contribution of cellular senescence to the time-to-healing of chronic wounds.
Main Methods
- A cohort of 79 patients with chronic wounds was evaluated.
- Clinical data and wound biopsies were collected at baseline.
- Biopsies were analyzed for pathological characteristics and cellular senescence markers, including p16INK4a expression.
Main Results
- No significant associations were found between clinical or pathological characteristics and time-to-healing.
- Increased CDKN1A (p21CIP1/WAF1) expression predicted longer time-to-healing.
- Increased p16INK4a staining was observed in diabetic wounds and wounds with high dermal fibrosis.
Conclusions
- Senescent cells appear to contribute to chronic wound healing delays in humans.
- Diabetic wounds may be particularly affected by cellular senescence.
- Further research is warranted to elucidate the precise mechanisms.
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
Related Concept Videos
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...