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Clinical Implications and Prognostic Value of Leucine-Rich G Protein-Coupled Receptor 5 Expression as A Cancer Stem
Sepideh Ghobakhloo1,2, Mehri Khoshhali3, Nasimeh Vatandoost1,2
1Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Cell Journal
|February 14, 2024
Summary
High Leucine-rich G protein-coupled receptor 5 (LGR5) expression correlates with poorer cancer patient survival and advanced disease stages. This finding suggests LGR5 may be a potential prognostic marker for certain cancer types, aiding in survival prediction.
Area of Science:
- Oncology
- Molecular Biology
- Biomarker Research
Background:
- Leucine-rich G protein-coupled receptor 5 (LGR5) is recognized as a cancer stem cell marker across diverse malignancies.
- Existing research presents conflicting data regarding the association between LGR5 expression and patient prognosis or clinicopathological features.
Approach:
- A systematic review and meta-analysis were conducted, searching major databases (EMBASE, PubMed, Science Direct, Scopus) up to December 21, 2022.
- Statistical measures including hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were employed.
- Data from 53 studies encompassing 9523 cancer patients were analyzed using STATA 12.0 software.
Key Points:
- Elevated LGR5 expression was significantly linked to diminished overall survival (OS) in cancer patients.
- High LGR5 levels correlated with advanced tumor stage, distant metastasis, and lymph node metastasis.
- Subgroup analyses indicated that study region, detection method, and cancer type modulate the prognostic impact of LGR5.
Conclusions:
- Overexpression of LGR5 is associated with unfavorable overall survival in cancer patients.
- Clinicopathological data further support an adverse prognosis for patients with high LGR5 expression.
- LGR5 demonstrates potential as a prognostic biomarker for survival prediction in specific cancer types.
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