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Severe SARS-CoV-2 and respiratory syncytial virus co-infection in two children

Andreana Angelova1, Mariya Atanasova1, Kostadin Ketev1

  • 1Medical University of Plovdiv, Plovdiv, Bulgaria.

Folia Medica
|February 14, 2024
PubMed

Insights

Severe COVID-19 in children is rare but possible, especially with coinfections like respiratory syncytial virus. Early diagnosis with multiplex PCR is crucial for managing pediatric cases and preventing spread.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Virology

Background:

  • Coronavirus Disease 2019 (COVID-19), caused by SARS-CoV-2, primarily impacts older adults.
  • Children typically experience milder COVID-19 symptoms, with severe cases being infrequent.
  • Comorbidities increase the risk of severe COVID-19 and mortality in adults.

Purpose of the Study:

  • To highlight the potential for severe COVID-19 in pediatric patients.
  • To emphasize the possibility of coinfections, such as with respiratory syncytial virus (RSV), leading to severe illness in children.
  • To underscore the importance of accurate and timely diagnosis in managing pediatric COVID-19 cases.

Main Methods:

  • Case report of two pediatric patients with severe COVID-19.
  • Utilized multiplex PCR for microbiological diagnosis.
  • Implemented contact precautions based on diagnostic results.

Main Results:

  • Identified coinfection with SARS-CoV-2 and RSV in two children presenting with severe COVID-19.
  • Multiplex PCR enabled early and accurate diagnosis.
  • Diagnostic findings facilitated prompt implementation of infection control measures.

Conclusions:

  • Coinfection can significantly influence the clinical course and outcome of pediatric COVID-19.
  • Multiplex PCR is a valuable tool for diagnosing viral coinfections in children.
  • Further research is needed to understand the impact of coinfections on pediatric COVID-19 severity.

Keywords:
COVID-19 multiplex PCR RSV severity

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