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Updated: Jul 3, 2025
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Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
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Extreme oncoplasty: past, present and future.
René Aloisio da Costa Vieira1,2,3,4, Regis Resende Paulinelli1,5, Idam de Oliveira-Junior1,2,5
1Postgraduate Program in Tocogynecology, Botucatu School of Medicine, Botucatu, SP, Brazil.
Frontiers in Oncology
|February 14, 2024
Summary
Extreme oncoplasty (EO) expands breast-conserving surgery (BCS) options for mastectomy candidates with large or complex tumors. This review details new indications and surgical techniques for improved BCS rates.
Area of Science:
- Surgical Oncology
- Plastic Surgery
- Breast Cancer Treatment
Background:
- Breast surgery has evolved from mastectomy to breast-conserving surgery (BCS).
- Breast oncoplastic surgery integrates plastic surgery techniques for breast cancer.
- Extreme oncoplasty (EO) is a new paradigm for mastectomy candidates with large, multifocal, or multicentric tumors previously ineligible for BCS.
Approach:
- This review evaluates indications and surgical procedures within the context of extreme oncoplasty (EO).
- The objective is to present EO as a new perspective for breast-conserving surgery (BCS).
Key Points:
- New indications for EO include extensive microcalcifications, locally advanced breast carcinoma with partial chemotherapy response, central tumors in small/non-ptotic breasts, and extreme ptosis.
- Small breasts can be candidates for EO if ptosis is present.
- Novel surgical techniques reported include disguised geometric compensation, perforator flaps, local/regional flaps, latissimus dorsi miniflap, and partial breast amputation.
Conclusions:
- Extreme oncoplasty (EO) broadens the scope of breast-conserving surgery (BCS) for a wider range of breast cancer patients.
- Reducing barriers to oncoplastic surgery is crucial for increasing the adoption of EO and overall BCS rates.
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