Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

244
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
244
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

145
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
145
Assessment of the Rectum and Anus01:25

Assessment of the Rectum and Anus

220
Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
220
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

334
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
334
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

450
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
450

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Performance of Google NotebookLM for AI-assisted data extraction and consensus statement generation in a heterogenous systematic review on inflammatory bowel disease, obesity, and cardiometabolic comorbidities: A Methodological Report.

medRxiv : the preprint server for health sciences·2026
Same author

Novel mouse models for perianal fistulizing Crohn's disease reveal therapeutic value of interferon-γ antagonists.

bioRxiv : the preprint server for biology·2026
Same author

Adrenal lesions in young adults: variability in radiology reporting and implications for clinical evaluation.

Abdominal radiology (New York)·2026
Same author

Unlocking multi-institutional insights into disease progression with PEAL as a lossless, one-shot federated learning solution.

NPJ digital medicine·2026
Same author

Implementation of a New MRI Contrast Policy at a Large Hospital System: Access to Contrast-Enhanced MRI and Development of NSF in Patients with Renal Insufficiency.

Academic radiology·2026
Same author

Zero-shot Thoracic Oncologic History Generation for Radiologists Using Retrieval-augmented Large Language Model Pipeline.

Radiology·2026

Related Experiment Video

Updated: Jul 3, 2025

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
15:49

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

Published on: October 16, 2013

31.8K

Geldof Expert Consensus Classification of Perianal Fistulizing Crohn's Disease: A Real-World Application in a Serial

Matthew Schroeder, Suha Abushamma, Alvin T George

    Medrxiv : the Preprint Server for Health Sciences
    |February 14, 2024
    PubMed
    Summary
    This summary is machine-generated.

    The Geldof classification shows perianal fistulizing Crohn's disease (CD-PAF) changes over time. Male sex was linked to improved classification, but predicting transitions remains challenging.

    More Related Videos

    Murine Endoscopy for In Vivo Multimodal Imaging of Carcinogenesis and Assessment of Intestinal Wound Healing and Inflammation
    09:42

    Murine Endoscopy for In Vivo Multimodal Imaging of Carcinogenesis and Assessment of Intestinal Wound Healing and Inflammation

    Published on: August 26, 2014

    18.7K
    Murine Ileocolic Bowel Resection with Primary Anastomosis
    08:49

    Murine Ileocolic Bowel Resection with Primary Anastomosis

    Published on: October 29, 2014

    16.4K

    Related Experiment Videos

    Last Updated: Jul 3, 2025

    Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
    15:49

    Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

    Published on: October 16, 2013

    31.8K
    Murine Endoscopy for In Vivo Multimodal Imaging of Carcinogenesis and Assessment of Intestinal Wound Healing and Inflammation
    09:42

    Murine Endoscopy for In Vivo Multimodal Imaging of Carcinogenesis and Assessment of Intestinal Wound Healing and Inflammation

    Published on: August 26, 2014

    18.7K
    Murine Ileocolic Bowel Resection with Primary Anastomosis
    08:49

    Murine Ileocolic Bowel Resection with Primary Anastomosis

    Published on: October 29, 2014

    16.4K

    Area of Science:

    • Gastroenterology
    • Inflammatory Bowel Disease Research
    • Medical Imaging in Crohn's Disease

    Background:

    • Perianal fistulizing Crohn's disease (CD-PAF) is a severe form of Crohn's disease with frequent relapses.
    • A novel Geldof classification system aims to unify disease severity and patient goals but requires validation.
    • This study validates the Geldof classification in a real-world cohort and explores predictive factors for class transitions.

    Approach:

    • Retrospectively analyzed 100 patients with CD-PAF and at least two pelvic MRIs (pMRI).
    • Collected data on Geldof Classification, disease characteristics, and pMRI indices at baseline and follow-up.
    • Utilized linear mixed-effect modeling to identify factors associated with classification changes.

    Key Points:

    • Over half of patients (52.1%) experienced a change in their Geldof classification over time.
    • Male sex and prior perianal surgery were more common in patients who improved their classification.
    • Improvements in MRI indices (mVAI, MODIFI-CD, PEMPAC) correlated with improved classification, though baseline MRI indices did not predict changes.

    Conclusions:

    • The Geldof classification effectively illustrates the dynamic nature of CD-PAF.
    • While male sex showed a correlation with improvement, predicting class transitions requires further investigation, ideally through prospective studies.
    • Improvements in imaging biomarkers are associated with a transition to lower severity classes within the Geldof system.