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Updated: Jul 3, 2025

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase
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Published on: April 29, 2010

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NELF coordinates Pol II transcription termination and DNA replication initiation.

Chihiro Nakayama, Yasukazu Daigaku, Yuki Aoi

    Biorxiv : the Preprint Server for Biology
    |February 14, 2024
    PubMed
    Summary

    Colorectal tumors show increased NELF-C gene expression. Loss of NELF-C disrupts RNA polymerase II transcription termination and elongation, potentially causing transcription-replication conflicts and impacting cell cycle progression.

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