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Decreased Left Atrial Cardiomyocyte FGF13 Expression Increases Vulnerability to Postoperative Atrial Fibrillation in
Biorxiv : the Preprint Server for Biology
|February 14, 2024
Summary
Decreased fibroblast growth factor 13 (FGF13) in heart tissue is linked to new-onset postoperative atrial fibrillation (POAF) after mitral valve surgery. Lower FGF13 levels may increase susceptibility to this common cardiac complication.
Area of Science:
- Cardiology
- Molecular Biology
- Cardiac Surgery
Background:
- Postoperative atrial fibrillation (POAF) is a frequent complication following cardiac surgery, contributing to significant morbidity and mortality.
- Current understanding of the molecular mechanisms driving POAF remains limited, hindering the development of targeted therapies.
Conclusions:
- Reduced FGF13 expression in atrial tissue is strongly associated with new-onset POAF after cardiac surgery.
- Decreased FGF13 may promote atrial myocyte electrical instability, increasing vulnerability to POAF.
- FGF13 represents a potential therapeutic target for preventing POAF.
