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The Blood-brain Barrier

The Blood-brain Barrier

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Updated: Jul 3, 2025

Generation of a Human iPSC-Based Blood-Brain Barrier Chip

Generation of a Human iPSC-Based Blood-Brain Barrier Chip

Published on: March 2, 2020

Lab-on-a-chip models of the blood-brain barrier: evolution, problems, perspectives.

Mária A Deli¹, Gergő Porkoláb^1,2, András Kincses¹

¹HUN-REN Biological Research Centre, Institute of Biophysics, Szeged, Hungary. deli.maria@brc.hu.

|February 14, 2024

Summary

Lab-on-a-chip devices offer advanced blood-brain barrier (BBB) modeling for research. These BBB-on-chip models show promise as alternatives to animal testing in preclinical studies.

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Area of Science:

Biomedical Engineering
Neuroscience
Drug Delivery

Background:

Significant advancements in lab-on-a-chip technology have enabled sophisticated blood-brain barrier (BBB) modeling.
BBB-on-chip devices are increasingly utilized for studying BBB physiology, transport, and pathology.

Purpose of the Study:

To review current BBB-on-chip models and their applications.
To identify knowledge gaps and suggest future research directions for optimizing BBB-on-chip technology.

Main Methods:

Discussion of various BBB-on-chip model types.
Analysis of cell type selection's impact on physiological relevance.
Identification of engineering and cell biology challenges.

Main Results:

BBB-on-chip models are valuable tools for investigating BBB functions.
The choice of cell types critically influences model translatability.
Existing literature presents inconsistencies requiring further investigation.

Conclusions:

BBB-on-chip models hold great potential as predictive tools and replacements for animal experiments.
Interdisciplinary collaboration involving materials science, bioengineering, and biology is crucial.
Standardized characterization parameters are needed for chip and BBB model components.