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Fibrotic lung diseases in children

Birce Sunman1, Nural Kiper1

  • 1Department of Pediatric Pulmonology, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Pediatric Pulmonology
|February 14, 2024
PubMed

Insights

Pediatric pulmonary fibrosis (PF), a rare condition within interstitial lung disease (ILD), lacks clear diagnostic algorithms. This review synthesizes current knowledge to guide diagnosis and treatment of fibrosing ILD in children.

Area of Science:

  • Pediatric Pulmonology
  • Interstitial Lung Disease
  • Fibrotic Lung Disease

Background:

  • Pulmonary fibrosis (PF) is rare in children and often presents as part of interstitial lung disease (ILD).
  • Current diagnostic criteria for adult PF are not directly applicable to pediatric cases.
  • Accurate diagnosis of pediatric PF is crucial for initiating targeted therapies.

Purpose of the Study:

  • To provide a comprehensive overview of pediatric PF.
  • To address uncertainties in the diagnosis and management of PF in children.
  • To draw upon adult research to inform pediatric approaches.

Main Methods:

  • Literature review focusing on pediatric PF and fibrosing ILD.
  • Analysis of diagnostic approaches from existing pediatric studies.
  • Synthesis of information from adult PF research for pediatric application.

Main Results:

  • Diagnostic algorithms for pediatric PF are not well-established.
  • High-resolution computed tomography (HRCT) and lung biopsy are valuable diagnostic tools.
  • Optimal timing for antifibrotic treatment in pediatric PF remains unclear.

Conclusions:

  • Further research is needed to establish clear diagnostic criteria for pediatric PF.
  • A multidisciplinary approach is essential for managing children with fibrosing ILD.
  • Adapting adult PF knowledge requires careful consideration of pediatric-specific factors.

Keywords:
antifibroticchildreninterstitial lung diseasenintedanibpirfenidonepulmonary fibrosis

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