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  11. Referral Patterns Of Gist Patients: Data From A Nationwide Study

Referral patterns of GIST patients: data from a nationwide study

Evelyne Roets1, Nikki S Ijzerman2, Vincent K Y Ho3

  • 1Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.

Acta Oncologica (Stockholm, Sweden)
|February 14, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Gastrointestinal stromal tumor (GIST) patients diagnosed in non-reference centers often lack systemic treatment, particularly metastatic cases. Optimizing referral strategies in the Netherlands could improve GIST patient outcomes.

Area of Science:

  • Oncology
  • Gastroenterology
  • Health Services Research

Background:

  • Gastrointestinal stromal tumors (GIST) represent a significant challenge in oncology.
  • Treatment disparities may exist between specialized reference centers and general non-reference centers.

Purpose of the Study:

  • To compare GIST patient characteristics, referral patterns, and treatment across Dutch reference and non-reference centers.
  • To evaluate the impact of center type on systemic therapy administration and outcomes.

Main Methods:

  • Retrospective cohort study using the Netherlands Cancer Registry and Dutch Nationwide Pathology Database (2016-2019).
  • Patients categorized into reference center (diagnosed or referred) and non-reference center (no referral) groups.
  • Analysis of referral rates, mutation analysis, systemic therapy, and surgical outcomes.

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Main Results:

  • 1,550 GIST patients included; 87% diagnosed in non-reference centers.
  • Referral rates higher for high-risk (62.2%) and metastatic (67.2%) GIST patients.
  • Systemic therapy less frequent in non-reference centers for metastatic GIST (65.9% vs 94.1%). Mutation analysis more common in reference centers (96.9% vs 87.6%).

Conclusions:

  • A significant proportion of metastatic GIST patients in non-reference centers did not receive systemic treatment.
  • Referral optimization for GIST patients in the Netherlands is warranted.
  • Further research is needed to understand reasons for undertreatment in metastatic GIST.