Advancing Global Health Surveillance of Mycotoxin Exposures using Minimally Invasive Sampling Techniques: A State-of-the-Science Review
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Summary
This summary is machine-generated.New minimally invasive assays using dried blood spots (DBS) and volumetric tip microsampling (VTS) can monitor human exposure to harmful mycotoxins. These validated methods support global public health surveillance and policy interventions.
Area Of Science
- Environmental Health
- Toxicology
- Analytical Chemistry
Background
- Mycotoxins produced by fungi contaminate staple crops, posing significant health risks through human consumption and inhalation.
- Widespread exposure necessitates reliable methods for monitoring human exposure levels.
Purpose Of The Study
- To review and summarize studies developing and validating minimally invasive assays for mycotoxin detection in human biological samples.
- To highlight future directions for improving and deploying these assays as global public health tools.
Main Methods
- Systematic literature search of PubMed, Embase, and CINAHL databases.
- Extraction and critical review of key assay performance metrics for dried blood spot (DBS), dried serum spot (DSS), and volumetric tip microsampling (VTS) assays.
- Identification of 11 relevant published reports on mycotoxin measurement using these methods.
Main Results
- Multimycotoxin assays adapted for DBS/DSS and VTS have demonstrated sufficient laboratory validation for population health studies.
- The reviewed assays primarily focused on ochratoxins, aflatoxins, and fumonisins.
- Current methods show promise for large-scale human biomonitoring.
Conclusions
- Validated minimally invasive sampling techniques, including DBS and VTS, are crucial for public health surveillance of mycotoxin exposure.
- Future research should expand the range of detectable mycotoxins, improve assay sensitivity, and validate methods across diverse populations.
- Deployment of low-cost, ultrasensitive, and minimally invasive methods can inform policies to reduce global mycotoxin exposure inequities.
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