Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Collaborative Behavioral Teratology Study: statistical approach.

C J Nelson, R P Felton, C A Kimmel

    Neurobehavioral Toxicology and Teratology
    |November 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Chronic Cocaine Treatment Alters Social/Aggressive Behavior in Sprague-Dawley Rat Dams and in Their Prenatally Exposed Offspring<sup>a</sup>.

    Annals of the New York Academy of Sciences·2017
    Same author

    Protective effect of Allium sativum (garlic) aqueous extract against lead-induced oxidative stress in the rat brain, liver, and kidney.

    Environmental science and pollution research international·2016
    Same author

    Erectile function recovery in patients after non-nerve sparing radical prostatectomy.

    Andrology·2014
    Same author

    Seasonal and intraplant variation of cardenolide content in the California milkweed,Asclepias eriocarpa, and implications for plant defense.

    Journal of chemical ecology·2014
    Same author

    Plant-determined variation in the cardenolide content, thin-layer chromatography profiles, and emetic potency of monarch butterflies,Danaus plexippus reared on the milkweed,Asclepias eriocarpa in California.

    Journal of chemical ecology·2014
    Same author

    Plant-determined variation in cardenolide content and thin-layer chromatography profiles of monarch butterflies,Danaus plexippus reared on milkweed plants in California : 3. Asclepias californica.

    Journal of chemical ecology·2013
    Same journal

    Effects of single exposure to toluene on shock avoidance and time estimation in rats.

    Neurobehavioral toxicology and teratology·1986
    Same journal

    Attention, distraction and reaction time at age 7 years and prenatal alcohol exposure.

    Neurobehavioral toxicology and teratology·1986
    Same journal

    Behavioral effects of chronic manganese administration in rats: locomotor activity studies.

    Neurobehavioral toxicology and teratology·1986
    Same journal

    Duration and intensity of behavioral change after sublethal exposure to soman in rats.

    Neurobehavioral toxicology and teratology·1986
    Same journal

    Acute sulfolane exposure produces temperature-independent and dependent changes in visual evoked potentials.

    Neurobehavioral toxicology and teratology·1986
    Same journal

    Behavioral, neurochemical and physiological effects of repeated exposures to subsymptomatic levels of the anticholinesterase, soman.

    Neurobehavioral toxicology and teratology·1986
    See all related articles

    This study on developmental toxicology found that early testing experience in pups did not affect outcomes for d-amphetamine sulfate or methylmercuric chloride. Results highlight the reliability and sensitivity of behavioral teratology methods.

    Area of Science:

    • Neuroscience
    • Developmental Toxicology
    • Pharmacology

    Background:

    • Behavioral teratology studies assess the impact of chemical exposure on neurodevelopment.
    • Standardized protocols are crucial for reliable and reproducible results across multiple laboratories.

    Purpose of the Study:

    • To evaluate the reliability and sensitivity of a collaborative behavioral teratology study design.
    • To determine the effects of early testing experience on behavioral outcomes.
    • To assess the suitability of different experimental units (litter vs. pup) in teratology research.

    Main Methods:

    • Utilized a multi-laboratory design with two test compounds: d-amphetamine sulfate and methylmercuric chloride.
    • Employed a detailed experimental structure with multiple doses, replicates, litters, and pups per litter.

    Related Experiment Videos

  • Applied a repeated measures analysis of variance (ANOVA) for data analysis.
  • Included a comparison between pups with early testing experience and naive pups.

    • Main Results:

    • The study design demonstrated reliability and sensitivity in detecting effects of the tested compounds.
    • Early testing experience did not significantly alter the outcomes for either d-amphetamine sulfate or methylmercuric chloride.
    • The analysis discussed the appropriate experimental unit, considering litter and pup levels.

    Conclusions:

    • The Collaborative Behavioral Teratology Study design is a reliable and sensitive method for assessing behavioral teratogenicity.
    • Early experience testing does not appear to confound results for the tested compounds in this model.
    • Further consideration of experimental unit choice is important for robust teratological study design.