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Collaborative Behavioral Teratology Study: results.

J Buelke-Sam, C A Kimmel, J Adams

    Neurobehavioral Toxicology and Teratology
    |November 1, 1985
    PubMed
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    This study evaluated behavioral tests in the Collaborative Behavioral Teratology Study (CBTS) using d-amphetamine sulfate and methylmercuric chloride. The methods showed reproducibility and sensitivity for detecting developmental toxicity.

    Area of Science:

    • Neuroscience
    • Developmental Biology
    • Toxicology

    Background:

    • The Collaborative Behavioral Teratology Study (CBTS) utilized various behavioral measures to assess developmental toxicity.
    • Standardized protocols are crucial for evaluating the reproducibility and sensitivity of behavioral tests.

    Purpose of the Study:

    • To assess the reproducibility and detection sensitivity of behavioral test methods within the CBTS.
    • To investigate the impact of early testing on later assessments, sex differences, and sources of variation in behavioral measures.
    • To evaluate developmental toxicity following prenatal exposure to d-amphetamine sulfate and methylmercuric chloride.

    Main Methods:

    • Employed negative geotaxis, olfactory discrimination, auditory startle habituation, and activity tests at various postnatal days (PNDs).

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  • Included a visual discrimination task, maternal/offspring weight monitoring, and physical development landmark assessment.
  • Administered prenatal d-amphetamine sulfate (Study 1) or methylmercuric chloride (Study 2) at different dosage levels.

    • Main Results:

    • Behavioral measures demonstrated varying degrees of reproducibility and sensitivity in detecting toxicity.
    • Early testing experience and offspring sex influenced behavioral responses and variability.
    • Prenatal exposure to d-amphetamine sulfate and methylmercuric chloride induced observable toxic effects.

    Conclusions:

    • The CBTS behavioral test battery is a valuable tool for assessing developmental neurotoxicity.
    • Standardization and consideration of factors like sex and testing history are essential for accurate interpretation of results.
    • The study successfully identified toxic effects of d-amphetamine sulfate and methylmercuric chloride on behavioral development.