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Updated: Jul 3, 2025
08:49
Visualization of Cortical Modules in Flattened Mammalian Cortices
Published on: January 22, 2018
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Tumour-infiltrated cortex participates in large-scale cognitive circuits
Ayan S Mandal1, Chemda Wiener2, Moataz Assem3
1Brain-Gene Development Lab, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, USA; Brain Mapping Unit, Department of Psychiatry, University of Cambridge, UK.
Summary
Diffuse gliomas infiltrate brain tissue, yet its role in cognitive function is unclear. This study shows tumor-infiltrated cortex participates in executive function networks, linking connectivity to patient outcomes.
Area of Science:
- Neuroscience
- Cognitive Science
- Oncology
Background:
- The contribution of tumor-infiltrated brain tissue to cognitive function is not well understood.
- Diffuse gliomas often infiltrate cortical areas crucial for cognition.
Purpose of the Study:
- To investigate if tumor-infiltrated cortical tissue participates in large-scale cognitive circuits.
- To assess the relationship between functional connectivity of infiltrated tissue and cognitive outcomes.
Main Methods:
- Combined intracranial electrocorticography (ECoG) and resting-state functional magnetic resonance imaging (fMRI).
- Assessed task-related high gamma power modulations during cognitive tasks.
- Analyzed functional connectivity patterns with canonical brain networks.
Main Results:
- Tumor-infiltrated cortex showed preserved functionality, with significant high gamma power modulations during executive function tasks.
- Task-responsive regions exhibited functional connectivity with executive function networks, particularly the dorsal attention network (DAN).
- Tumor-DAN connectivity correlated with long-term postsurgical outcomes in goal-directed attention.
Conclusions:
- Tumor-infiltrated cortex actively participates in large-scale neurocognitive circuits supporting executive function.
- Mapping the functional connectivity of infiltrated tissue may have clinical utility in managing diffuse gliomas.
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