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Reflex modification as a test for sensory function.

J R Wecker, J R Ison, J A Foss

    Neurobehavioral Toxicology and Teratology
    |November 1, 1985
    PubMed
    Summary
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    Reflex modification is a sensitive tool for assessing auditory function development and damage. This method, unlike reflex elicitation alone, reveals subtle, frequency-specific hearing deficits in rats exposed to noise or ototoxic drugs.

    Area of Science:

    • Neuroscience
    • Auditory Neuroscience
    • Sensory Physiology

    Background:

    • Reflex modification is a valuable technique for evaluating sensory system responses to various stimuli.
    • It involves eliciting a reflex and then modifying it with preliminary stimuli.
    • This method has been used to study auditory development and the effects of insults on hearing.

    Purpose of the Study:

    • To examine the normal development of auditory function in rats using reflex modification and elicitation.
    • To evaluate alterations in auditory function caused by noise exposure and toxic insult.
    • To compare the sensitivity and specificity of reflex modification versus reflex elicitation.

    Main Methods:

    • Utilized reflex modification and reflex elicitation procedures in rats.

    Related Experiment Videos

  • Exposed adult rats to octave bands of noise.
  • Administered kanamycin to developing rats during a critical period of auditory development.

    • Main Results:

    • Adult rats exposed to noise showed frequency-specific deficits in reflex modification, but not reflex elicitation.
    • In developing rats, reflex elicitation emerged by postnatal day 12, and modification by day 14.
    • Kanamycin exposure caused dose-related deficits in detecting high-frequency stimuli (32 and 16 kHz) without affecting reflex elicitation.

    Conclusions:

    • Reflex modification is a more sensitive and specific measure of auditory function than reflex elicitation alone.
    • Auditory development in rats involves the emergence of both reflex elicitation and modification.
    • Noise exposure and kanamycin ototoxicity induce frequency-specific auditory deficits detectable by reflex modification.