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Related Concept Videos

Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

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Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
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Gross Anatomy of the Liver01:17

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The liver, the largest gland within the human body, is a firm and reddish-brown organ. This wedge-shaped structure weighs approximately 1.5 kg and occupies a significant portion of the right hypochondriac and epigastric regions. It extends more to the right of the body's midline than to the left.
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Chronic Pancreatitis II: Collaborative Care01:29

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The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
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Hepatic Drug Clearance: Role of Transporters01:14

Hepatic Drug Clearance: Role of Transporters

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In the liver and bile canaliculi, influx and efflux transporters modification can influence intrinsic clearance. Transporters play a significant role in moving drugs within liver cells. Elaborate models, such as the Biopharmaceutical Classification System (BCS), are essential to relate transporters to drug disposition. This system categorizes drugs into four classes based on solubility and permeability, providing insights into elimination routes and the effects of transporters following oral...
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Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
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Hepatic Drug Excretion: Influencing Factors01:16

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The biliary system of the liver, crucial for bile secretion and drug excretion, comprises intrahepatic bile ducts that merge to form the common hepatic duct. This duct, carrying hepatic bile, combines with the cystic duct, draining the gallbladder and forming the common bile duct, which empties into the duodenum. Bile, produced by hepatic cells lining the bile canaliculi, is composed primarily of water, bile salts, pigments, electrolytes, and lesser amounts of cholesterol and fatty acids. Bile...
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Occult liver disease: A multinational perspective.

Paulina Vidal-Cevallos1, Nayelli Flores-García2, Norberto C Chávez-Tapia1

  • 1Obesity and Digestive Disease Unit, Medica Sur Clinic and Foundation, Puente de Piedra 150, Toriello Guerra, 14050, Mexico City, Mexico.

Annals of Hepatology
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PubMed
Summary
This summary is machine-generated.

Occult liver disease, often unrecognized, is a significant global health issue. Early screening and treatment, particularly for non-alcoholic fatty liver disease (NAFLD) and viral hepatitis, are crucial for reducing mortality.

Keywords:
Alcoholic liver diseaseCirrhosisEpidemiologyLatin AmericaNon-alcoholic fatty liver diseaseViral hepatitis

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Area of Science:

  • Hepatology
  • Public Health
  • Epidemiology

Background:

  • Liver disease is the 11th leading global cause of death, responsible for 4% of all deaths.
  • Alcohol consumption is the primary driver of cirrhosis (60% of cases), while non-alcoholic fatty liver disease (NAFLD) prevalence is rising globally (estimated 32.4%).
  • Viral hepatitis B and C caused 1.3 million deaths in 2020, highlighting the burden of infectious liver diseases.

Purpose of the Study:

  • To underscore the significance of occult liver disease, defined as unrecognized chronic liver disease and cirrhosis.
  • To highlight the need for assessing occult liver disease prevalence in Latin America, a region with high rates of metabolic diseases and alcohol consumption.
  • To advocate for targeted screening and early intervention strategies for liver disease.

Main Methods:

  • Review of global liver disease statistics and risk factors.
  • Identification of high-risk populations for occult liver disease, including those with elevated liver enzymes, type 2 diabetes, and excessive alcohol consumption.
  • Emphasis on screening strategies for non-alcoholic fatty liver disease (NAFLD) and alcohol use disorders.

Main Results:

  • Studies indicate a high prevalence of occult liver disease in at-risk populations.
  • Latin America presents a critical region for further investigation due to high metabolic disease and alcohol consumption rates.
  • Early detection and intervention are key to mitigating liver disease burden.

Conclusions:

  • Occult liver disease represents a substantial, often undetected, health burden globally.
  • Targeted screening for NAFLD and alcohol-related liver disease in high-risk individuals is essential.
  • Prompt treatment of occult liver disease, including viral hepatitis, can prevent progression and transmission, reducing overall mortality.