Solid pseudopapillary neoplasms of the pancreas: Multicenter Vasepa study.

Area of Science:

• Gastroenterology
• Surgical Oncology
• Pathology

Background:

• Solid pseudopapillary tumors (SPT) are uncommon exocrine pancreatic neoplasms.
• Preoperative diagnosis can be challenging, with surgical excision being the primary treatment.
• SPT generally have a favorable prognosis and high disease-free survival rates post-resection.

Purpose of the Study:

• To detail the clinicopathological and radiological features of SPT patients.
• To evaluate short- and long-term outcomes following surgical resection of SPT.
• To assess surgical success rates and patient survival post-SPT treatment.

Main Methods:

• A multicenter retrospective observational study was conducted.
• Data from patients undergoing SPT surgery between January 2000 and January 2022 were analyzed.
• Preoperative, intraoperative, and postoperative variables, along with follow-up data (mean 28 months), were examined.

Main Results:

• Twenty patients with histologically confirmed SPT were included; 90% were women, with a mean age of 33.5 years.
• Computed tomography (CT) was the primary diagnostic tool (90%), and tumors were most frequently located in the body-tail (60%).
• The R0 resection rate was 95%, with a 5-year disease-free survival of 95%; major postoperative complications occurred in 4 patients.

Conclusions:

• Solid pseudopapillary tumors are typically large, predominantly affect women, and are often found in the pancreatic body-tail.
• High R0 resection rates (95%) were achieved, indicating successful surgical management.
• The oncological outcomes for SPT patients treated with surgery are excellent.