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Related Concept Videos

  • Biomedical And Clinical Sciences
  • Oncology And Carcinogenesis
  • Predictive And Prognostic Markers
  • Quantitative Parameters Of Contrast-enhanced Ultrasound Effectively Promote The Prediction Of Cervical Lymph Node Metastasis In Papillary Thyroid Carcinoma.
  • Biomedical And Clinical Sciences
  • Oncology And Carcinogenesis
  • Predictive And Prognostic Markers
  • Quantitative Parameters Of Contrast-enhanced Ultrasound Effectively Promote The Prediction Of Cervical Lymph Node Metastasis In Papillary Thyroid Carcinoma.

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    Quantitative parameters of contrast-enhanced ultrasound effectively promote the prediction of cervical lymph node metastasis in papillary thyroid carcinoma.

    Biao Su1,2, Lisha Li3,4, Yingchun Liu1

    • 1Department of Ultrasound, Huadong Hospital, Fudan University, Shanghai, China.

    Drug Discoveries & Therapeutics
    |February 14, 2024

    View abstract on PubMed

    Summary
    This summary is machine-generated.

    Contrast-enhanced ultrasound (CEUS) quantitative parameters, specifically peak intensity (PI), can predict cervical lymph node metastasis in papillary thyroid carcinoma (PTC) larger than 10 mm. PI is not effective for smaller PTCs.

    Keywords:
    cervical lymph node metastasiscontrast-enhanced ultrasoundpapillary thyroid carcinomaquantitative parameter

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    Area of Science:

    • Oncology
    • Radiology
    • Endocrinology

    Background:

    • Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy.
    • Cervical lymph node metastasis (CLNM) is a frequent complication of PTC, impacting surgical decisions.
    • Accurate preoperative prediction of CLNM is crucial for optimal patient management.

    Purpose of the Study:

    • To evaluate the efficacy of quantitative contrast-enhanced ultrasound (CEUS) parameters in predicting CLNM in PTC.
    • To assess the diagnostic performance of CEUS parameters based on PTC tumor size (≤ 10 mm vs. > 10 mm).

    Main Methods:

    • Retrospective analysis of 193 patients with PTC who underwent conventional ultrasound (CUS) and CEUS.
    • Evaluation of CUS features and CEUS quantitative parameters (including peak intensity).
    • Pathology results served as the gold standard for CLNM diagnosis.

    Main Results:

    • For PTC > 10 mm, quantitative CEUS parameters, particularly peak intensity (PI), mean transit time, and slope, were significantly associated with CLNM.
    • PI > 5.8 dB was identified as an independent risk factor for predicting CLNM in PTC > 10 mm.
    • The combination of PI and CUS demonstrated superior predictive performance (AUC 0.831) compared to CUS (0.707) or PI (0.703) alone for larger PTCs.

    Conclusions:

    • Quantitative CEUS, specifically peak intensity (PI), is valuable for predicting cervical lymph node metastasis in papillary thyroid carcinoma larger than 10 mm.
    • CEUS quantitative parameters, including PI, did not show significant predictive value for CLNM in papillary thyroid carcinoma ≤ 10 mm.
    • The findings suggest a size-dependent utility of CEUS in assessing CLNM risk for PTC.