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Prognostic Significance Of Pt3a Staging Subclassifications In Renal Cell Carcinoma: Not All Pt3a Are Equal.

Home
Research Domains
Biomedical And Clinical Sciences
Oncology And Carcinogenesis
Predictive And Prognostic Markers
Prognostic Significance Of Pt3a Staging Subclassifications In Renal Cell Carcinoma: Not All Pt3a Are Equal.

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Published on: February 8, 2018

Prognostic significance of pT3a staging subclassifications in renal cell carcinoma: Not all pT3a are equal.

Michael E Rezaee¹, Maximilian Pallauf², Sean A Fletcher¹

¹The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD.

Urologic Oncology

|February 14, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

For patients with pT3a renal cell carcinoma (RCC), perinephric fat, renal sinus fat, and renal vein invasion significantly impact cancer-specific survival (CSS), especially in papillary RCC. These findings suggest refining pT3a staging criteria for better treatment strategies.

Keywords:

Kidney cancer Non-clear cell Prognosis Renal vein

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The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers

The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers

Published on: January 22, 2013

Area of Science:

Urology
Oncology
Pathology

Background:

Renal cell carcinoma (RCC) is a significant health concern.
Accurate staging is crucial for effective treatment planning in RCC.
The prognostic value of specific pT3a substages in RCC requires further elucidation.

Purpose of the Study:

To investigate the prognostic significance of perinephric fat, renal sinus fat, and renal vein invasion in patients with pT3a renal cell carcinoma (RCC).
To analyze these prognostic factors across different histological subtypes of RCC.

Main Methods:

A population-based retrospective cohort study utilizing Surveillance, Epidemiology, and End Results (SEER) data from 2010-2019.
Cox proportional hazards models were employed to assess cancer-specific survival (CSS) in relation to pT3a subclassification and histological subtype.

The study included 10,170 patients with pT3a RCC, categorized by clear cell and nonclear cell subtypes.

Main Results:

Differences in CSS were observed across pT3a subclassification groups in all histological subtypes, with the most pronounced effects in nonclear cell RCC, particularly papillary RCC.
Compared to perinephric fat invasion alone, renal vein invasion (HR=4.9), renal sinus fat invasion (HR=3.0), combined renal vein and perinephric fat invasion (HR=7.5), and invasion in all three sites (HR=4.4) were associated with worse CSS in papillary RCC.
Clear cell RCC showed less pronounced survival differences based on these pT3a substages.

Conclusions:

The prognostic role of pT3a staging subclassifications varies significantly by RCC histological subtype.
Papillary RCC demonstrates notable survival differences based on the extent of local invasion within the pT3a stage.
Refining pT3a staging criteria is essential for developing individualized, multimodal treatment strategies for locally advanced RCC.