Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Nose and Nasal Cavity

Nose and Nasal Cavity

The nose is composed of an observable exterior segment (external nose) and an internal segment within the skull known as the nasal cavity (internal nose). The external nose, visible on the face, consists of a framework of bone and hyaline cartilage enveloped in skin and muscle and lined with a mucous membrane. This structure is supported by the frontal bone, nasal bones, and maxillary bone and is supplemented by a cartilaginous framework comprising the septal nasal cartilage, lateral nasal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

PD-L2 is associated with lineage-related transcriptional programs distinct from PD-L1 in primary mediastinal large B-cell lymphoma.

Leukemia·2026

Same author

MiT fusions, TSC1-TSC2 divergence, and stem-like programs reveal distinct origins and vulnerabilities in PEComa.

Nature communications·2026

Same author

Low-Grade Nasopharyngeal Papillary Adenocarcinoma: Toward a Better Molecular, Epigenetic, and Clinicopathological Understanding With Ontological Perspective.

The American journal of surgical pathology·2026

Same author

Segmental Atrophy of the Liver: An Increasingly Recognized Pseudotumor With Distinct Clinicopathologic and Imaging Features.

The American journal of surgical pathology·2026

Same author

HPV in oropharyngeal squamous papillomas: a missing link in head and neck viral pathogenesis.

Virchows Archiv : an international journal of pathology·2026

Same author

International Consensus Guidelines for Diagnostic Criteria and Checklist for Future Studies for Minimally Invasive Carcinoma ex Pleomorphic Adenoma: An HN CLEAR Initiative.

Head and neck pathology·2026

Search research articles

Related Experiment Video

Updated: May 5, 2026

Intranasal Delivery of Therapeutic Stem Cells to Glioblastoma in a Mouse Model

Intranasal Delivery of Therapeutic Stem Cells to Glioblastoma in a Mouse Model

Published on: June 4, 2017

[Translocated sinonasal tumors].

Charles Lépine¹, Aude Trinquet², Marick Laé³

¹Service d'anatomie et cytologie pathologiques, Nantes université, CHU de Nantes, 44000 Nantes, France; Inserm, CNRS, Immunology and New Concepts in ImmunoTherapy (INCIT), UMR 1302/EMR6001, Nantes, France.

Annales De Pathologie

|February 14, 2024

Summary

This study reviews nasal cavity and sinus tumors with specific gene fusions, including DEK::AFF2 squamous cell carcinomas and sarcomas with EWSR1::FLI1 rearrangements. It details their morphology, immunohistochemistry, and prognosis.

Keywords:

Carcinoma Carcinome Fosses nasales Nasal cavity Rearrangement Réarrangement Sarcoma Sarcome Sinus

More Related Videos

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Published on: February 28, 2019

Related Experiment Videos

Last Updated: May 5, 2026

Intranasal Delivery of Therapeutic Stem Cells to Glioblastoma in a Mouse Model

Intranasal Delivery of Therapeutic Stem Cells to Glioblastoma in a Mouse Model

Published on: June 4, 2017

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Published on: February 28, 2019

Area of Science:

Oncology
Genetics
Pathology

Background:

Nasal cavity and sinus tumors can exhibit specific genetic rearrangements.
Fusion genes are increasingly identified in various neoplastic entities.
Accessory salivary glands in the sinonasal region can give rise to tumors.

Purpose of the Study:

To describe sinonasal entities characterized by specific gene fusions.
To provide morphological, immunohistochemical, and prognostic details for these entities.
To highlight the role of genetic alterations in sinonasal tumor classification.

Main Methods:

Review of literature on sinonasal tumors with gene fusions.
Morphological and immunohistochemical analysis of described entities.
Correlation of genetic findings with clinical and prognostic data.

Main Results:

DEK::AFF2 squamous cell carcinomas are identified.
Non-intestinal and non-salivary nasosinusal adenocarcinomas with ETV6 rearrangements are discussed.
Biphenotypic nasosinusal sarcomas (PAX3 rearrangements) and Ewing's adamantinoma-like sarcomas (EWSR1::FLI1 rearrangements) are characterized.

Conclusions:

Specific gene fusions are key diagnostic and prognostic markers in sinonasal tumors.
Accurate classification requires integrating morphological, immunohistochemical, and molecular data.
Understanding these genetic alterations aids in targeted therapy and improved patient outcomes.