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Related Concept Videos

Respiratory Volumes01:15

Respiratory Volumes

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Respiratory volumes are crucial metrics, meticulously measured to quantify the air exchanged in and out of the lungs during various phases of the breathing cycle. These precise measurements are vital for assessing lung function, diagnosing respiratory conditions, and monitoring overall respiratory health. Each parameter provides specific insights into the mechanics of breathing and the functional capacity of the lungs.
Tidal Volume (TV) Tidal volume (TV) is the air inhaled or exhaled in a...
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Assessment of Respiration01:23

Assessment of Respiration

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The respiratory system's basic structures and primary functions lay the foundation for nurses' comprehensive respiratory assessments. This assessment includes subjective and objective data to gauge the patient's respiratory health.
Subjective Assessment: Nurses interview the patient to gather information directly during the subjective assessment. It includes questions about the individual's medical history, medications, and symptoms, focusing on past respiratory conditions like...
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Respiratory Volumes and Capacities01:22

Respiratory Volumes and Capacities

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The respiratory system is responsible for the intake of oxygen and the expulsion of carbon dioxide from the body. Respiratory volumes describe the volume of air in the lungs at different phases of the respiratory cycle. Tidal volume is the air breathed in and out during normal, quiet breathing. Inspiratory reserve volume is the air that can be forcefully inspired beyond the tidal volume. In contrast, expiratory reserve volume refers to the air that can be expelled from the lungs after a normal...
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Respiratory Capacities01:24

Respiratory Capacities

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Respiratory capacities are crucial indicators of lung function, representing the maximum amount of air an individual's respiratory system can handle during various breathing phases.
One key metric is the Inspiratory Capacity (IC), which represents the maximum amount of air that can be inhaled with full effort. IC is calculated by summing the tidal volume and inspiratory reserve volume, typically ranging from 2.4 to 3.6 liters.
The Functional Residual Capacity (FRC) represents the air in the...
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Respiratory Volumes and Capacities I01:26

Respiratory Volumes and Capacities I

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Assessing the respiratory rate and rhythm for a complete minute is crucial for evaluating the breathing pattern. Even a minor increase in the patient's average respiratory rate, by as little as three to five breaths per minute, is an early and vital indicator of respiratory distress. Patients with a respiratory rate exceeding twenty-four breaths per minute require close monitoring to determine the physiological alterations. This careful observation is essential for prompt recognition and...
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Breathing01:05

Breathing

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The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
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Updated: Jul 3, 2025

Breath Collection from Children for Disease Biomarker Discovery
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A Clinical Breathomics Dataset.

Ping-Hung Kuo1, Yue-Chen Jhong2, Tien-Chueh Kuo2,3

  • 1National Taiwan University Hospital, No. 1, Changde St., Zhongzheng Dist., Taipei City, 100229, Taiwan.

Scientific Data
|February 14, 2024
PubMed
Summary
This summary is machine-generated.

This study generated a clinical breathomics dataset from 121 patients using GC-MS. The non-invasive breath molecule analysis aids in diagnosing and monitoring asthma, bronchiectasis, and COPD.

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Last Updated: Jul 3, 2025

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Area of Science:

  • Clinical Chemistry
  • Analytical Chemistry
  • Biomedical Science

Background:

  • Breath analysis offers a non-invasive method to detect biomarkers.
  • Volatile organic compounds (VOCs) in breath can indicate various physiological and pathological states.
  • Current diagnostic methods for respiratory diseases can be invasive or require specialized equipment.

Purpose of the Study:

  • To create a comprehensive clinical breathomics dataset.
  • To catalog VOCs associated with asthma, bronchiectasis, and chronic obstructive pulmonary disease (COPD).
  • To provide a reliable resource for advancing diagnostic and therapeutic strategies.

Main Methods:

  • Gas Chromatography-Mass Spectrometry (GC-MS) was employed for comprehensive analysis.
  • 121 patient samples were analyzed to generate the dataset.
  • Strict, uniform sample collection protocols ensured data consistency and reliability.

Main Results:

  • A substantial dataset of human clinical breath molecule data was compiled.
  • The dataset specifically includes VOC profiles for individuals with asthma, bronchiectasis, and COPD.
  • This catalog provides valuable insights into disease-specific breath biomarkers.

Conclusions:

  • The generated breathomics dataset is a significant resource for researchers and clinicians.
  • This non-invasive approach enhances capabilities for disease diagnosis and patient monitoring.
  • Further exploration of this dataset can lead to improved diagnostic tools and therapeutic interventions.