Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Non-enzymatic coupling of protometabolic reactions with a prebiotic redox cofactor.

Nature communications·2026
Same author

π-Enlargement in Porphyrin Macrocycles at Interfaces.

Angewandte Chemie (International ed. in English)·2026
Same author

A regenerative rehabilitation strategy based on rGO scaffolds and treadmill training boosts neural, vascular and muscle repair features in chronic hemisected rats.

Biomaterials·2026
Same author

Resonant Domain Wall Dynamics in a Three-Dimensional Magnetic Nano Double Helix.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Prevalence and characterization of pediatric-onset spinal cord injury pain as reported by youth: an observational and case control association study with TRPA1 gene single nucleotide polymorphisms.

Pain·2026
Same author

Substrate-Selective Temperature-Controlled Synthesis of Thiophene Derivatives at Interfaces.

Angewandte Chemie (International ed. in English)·2025
Same journal

Peripheral B-cell receptor repertoire predicts immune-related adverse events following immune checkpoint inhibitor therapy in advanced renal cell carcinoma.

Scientific reports·2026
Same journal

Effects of black soldier fly (Hermetia illucens L.) larvae zoocompost on the mineral element content of blue honeysuckle berries.

Scientific reports·2026
Same journal

Investigation on absorption refrigeration performance of R1243zf with imidazolium ionic liquid as the working pairs.

Scientific reports·2026
Same journal

DeepTriage-CN: integrating clinical text with vital signs for emergency department admission prediction in an aging population.

Scientific reports·2026
Same journal

Gold nanoparticles as dual-action antiviral agents: disruption of SARS-CoV-2 viral envelopes and RNA integrity.

Scientific reports·2026
Same journal

Comparison of capillary microsampling and venous blood for multi-pathogen serosurveillance.

Scientific reports·2026
See all related articles

Related Experiment Video

Updated: Jul 3, 2025

Fabrication of Ti3C2 MXene Microelectrode Arrays for In Vivo Neural Recording
09:58

Fabrication of Ti3C2 MXene Microelectrode Arrays for In Vivo Neural Recording

Published on: February 12, 2020

13.4K

Flexible metallic core-shell nanostructured electrodes for neural interfacing.

Beatriz L Rodilla1,2, Ana Arché-Núñez1, Sandra Ruiz-Gómez3

  • 1Fundación IMDEA Nanociencia, Calle Faraday 9, 28049, Madrid, Spain.

Scientific Reports
|February 14, 2024
PubMed
Summary
This summary is machine-generated.

Novel nanostructured electrodes with nickel-gold core-shell nanowires offer improved performance for neural interfaces. These flexible electrodes show significantly lower impedance and promote positive neural cell behavior in vitro.

More Related Videos

Fabrication of High Contact-Density, Flat-Interface Nerve Electrodes for Recording and Stimulation Applications
09:35

Fabrication of High Contact-Density, Flat-Interface Nerve Electrodes for Recording and Stimulation Applications

Published on: October 4, 2016

9.7K
Insertion of Flexible Neural Probes Using Rigid Stiffeners Attached with Biodissolvable Adhesive
06:40

Insertion of Flexible Neural Probes Using Rigid Stiffeners Attached with Biodissolvable Adhesive

Published on: September 27, 2013

14.8K

Related Experiment Videos

Last Updated: Jul 3, 2025

Fabrication of Ti3C2 MXene Microelectrode Arrays for In Vivo Neural Recording
09:58

Fabrication of Ti3C2 MXene Microelectrode Arrays for In Vivo Neural Recording

Published on: February 12, 2020

13.4K
Fabrication of High Contact-Density, Flat-Interface Nerve Electrodes for Recording and Stimulation Applications
09:35

Fabrication of High Contact-Density, Flat-Interface Nerve Electrodes for Recording and Stimulation Applications

Published on: October 4, 2016

9.7K
Insertion of Flexible Neural Probes Using Rigid Stiffeners Attached with Biodissolvable Adhesive
06:40

Insertion of Flexible Neural Probes Using Rigid Stiffeners Attached with Biodissolvable Adhesive

Published on: September 27, 2013

14.8K

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Neuroscience

Background:

  • Microelectrodes face charge-injection limitations in neural interfaces.
  • Nanostructured surfaces offer potential for improved neural electrode performance.
  • Core-shell nanowires combine material properties for enhanced functionality.

Purpose of the Study:

  • To develop flexible nanostructured electrodes using a novel template-assisted electrodeposition technique.
  • To create core-shell Nickel-Gold (Ni-Au) vertical nanowires for neural interfaces.
  • To evaluate the electrochemical and biocompatibility properties of these novel electrodes.

Main Methods:

  • Two-step template assisted electrodeposition for Ni-Au nanowire fabrication.
  • Electrochemical impedance spectroscopy (EIS) to measure electrode impedance.
  • Scanning electron microscopy (SEM) and cyclic voltammetry for surface area analysis.
  • In vitro cell culture studies with rat embryonic cortical cells.

Main Results:

  • Ni-Au nanostructured electrodes exhibited impedance at least 9 times lower than flat electrodes.
  • Effective surface area was significantly increased, with only gold exposed to the medium.
  • Electrochemical impedance spectroscopy profiles of Ni-Au electrodes remained stable over 7 days.
  • In vitro studies showed comparable cell morphology, viability, and neuronal differentiation to controls, with reduced glial differentiation.

Conclusions:

  • Ni-Au core-shell nanowire electrodes represent a promising advancement for low-impedance neural interfaces.
  • The enhanced surface area and biocompatibility of the gold shell contribute to improved performance.
  • Positive in vitro neural cell response warrants further in vivo investigation for neural tissue applications.