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Related Concept Videos

Anxiolytic Drugs: Benzodiazepines and Buspirone01:29

Anxiolytic Drugs: Benzodiazepines and Buspirone

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Benzodiazepines are a class of anxiolytic drugs known for their rapid efficacy and high therapeutic-to-lethal dose ratio, but with a potential risk of drug dependence. These drugs are lipophilic, allowing for rapid absorption after oral administration, eventually reaching the central nervous system (CNS). Once in the CNS, benzodiazepines bind to the allosteric site of the GABAA receptor. This binding enhances the inhibitory effects of the neurotransmitter GABA. By doing so, they prevent...
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Anxiolytic Drugs: Overview01:26

Anxiolytic Drugs: Overview

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Anxiolytic drugs are vital in managing anxiety disorders by effectively alleviating symptoms such as excessive fear, tachycardia, and tremors. There are several classes of anxiolytic medications, each with unique mechanisms of action and potential side effects.
Primary Types of Anxiolytic Drugs
1. Benzodiazepines:
Benzodiazepines bind to the GABA-A receptor in the brain, enhancing GABA's interaction. This action reduces neurotransmission, effectively blocking anxiety-associated limbic...
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Chemotherapy-Induced Nausea and Vomiting: Cannabinoids01:21

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

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Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
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Drug Therapy01:28

Drug Therapy

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The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
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Anxiety: Overview01:18

Anxiety: Overview

271
Anxiety is a common mental disorder featuring excessive worry, fear, and apprehension, significantly affecting daily life. People with anxiety disorders experience persistent and intense anxiety, interrupting their everyday functioning.
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
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Behavior Therapy01:22

Behavior Therapy

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Behavior therapy incorporates diverse techniques rooted in classical conditioning principles to address maladaptive behaviors and anxiety disorders. These methods aim to reduce avoidance behaviors, foster adaptive coping mechanisms, and alter associations between stimuli and responses, making them effective in a wide range of therapeutic contexts.
Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...
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Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

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RETRACTED: Masataka, N. Possible Anxiolytic Effects of Cannabidiol (CBD) Administration on Feline Responses to a Fear Response Test. <i>Animals</i> 2025, <i>15</i>, 1642.

Animals : an open access journal from MDPI·2026
Same author

RETRACTED: Possible Anxiolytic Effects of Cannabidiol (CBD) Administration on Feline Responses to a Fear Response Test.

Animals : an open access journal from MDPI·2025
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Possible effects of cannabidiol (CBD) administration on the vocal activity of healthy domestic dogs upon their temporary separation from caregivers.

Heliyon·2024
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Psycholinguistic analyses of alarm calls of Japanese monkeys (Macaca fuscata fuscata).

American journal of primatology·2020
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Effect of separation distance on isolation call structure in squirrel monkeys (Saimiri sciureus).

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Anxiolytic Effects of Repeated Cannabidiol Treatment in Teenagers With Social Anxiety Disorders.

Frontiers in psychology·2019

Related Experiment Video

Updated: Jul 3, 2025

Elevated Plus Maze Test Combined with Video Tracking Software to Investigate the Anxiolytic Effect of Exogenous Ketogenic Supplements
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Is cannabidiol (CBD) effective to ease separation anxiety?

Nobuo Masataka1

  • 1Center for Research of Developmental Disorders, Kyoto, Japan.

Heliyon
|February 15, 2024
PubMed
Summary

Cannabidiol (CBD) shows anxiety-reducing effects in cats. Studies indicate CBD administration decreased distress behaviors during separation, suggesting therapeutic potential for feline anxiety.

Area of Science:

  • Veterinary Medicine
  • Neuroscience
  • Pharmacology

Background:

  • Cannabidiol (CBD), a non-euphoric cannabis compound, shows therapeutic potential for neuropsychiatric disorders in humans.
  • The endocannabinoid system in domestic cats functions similarly to humans, suggesting CBD may have comparable effects.
  • Limited research exists on the clinical implications and efficacy of CBD in animal models, particularly for anxiety.

Purpose of the Study:

  • To evaluate the effects of CBD administration on separation anxiety in healthy cats.
  • To investigate whether CBD can mitigate anxiety-related behaviors in felines during brief caregiver separations.

Main Methods:

  • Ten healthy cats were administered either CBD (4.0 mg/kg/day for 2 weeks) or a placebo (sunflower oil).
  • Following administration, cats experienced brief separations from their caregivers.
Keywords:
AnxietyAttachmentCBDCannabidiolDomestic catFearSeparation

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  • Behavioral responses upon caregiver return were categorized into Secure Base Effect, excessive proximity, or disorganized behavior.

    • Main Results:

    • Cats spent more time in proximity to caregivers when receiving CBD compared to placebo.
    • Distress behaviors were more evident after placebo administration than after CBD administration.
    • The Secure Base Effect was more pronounced in cats receiving CBD, indicating reduced stress.

    Conclusions:

    • CBD administration demonstrated anxiety-reducing effects in cats during separation.
    • The findings suggest CBD has potential as a therapeutic agent for managing anxiety in felines.
    • Further clinical research is warranted to explore CBD's full therapeutic implications in veterinary medicine.