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Updated: Jul 28, 2026

Analyzing the α-Actinin Network in Human iPSC-Derived Cardiomyocytes Using Single Molecule Localization Microscopy
Published on: November 3, 2020
Characterizing induced pluripotent stem cells and derived cardiomyocytes: insights from nano scale mass measurements
Irene C Turnbull1, Angelo Gaitas2,3
1Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai New York NY 10029 USA irene.turnbull@mssm.edu.
Abstract:
Our study reveals that the nano-mechanical measures of elasticity and cell mass change significantly through induced pluripotent stem cell (iPSC) differentiation to cardiomyocytes, providing a reliable method to evaluate such processes. The findings support the importance of identifying these properties, and highlight the potential of AFM for comprehensive characterization of iPSC at the nanoscale.
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