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Identification of novel T cell proliferation patterns, potential biomarkers and therapeutic drugs in colorectal cancer

  • 0Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, Anhui, China.
Journal of Cancer +

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February 15, 2024

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February 15, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

This study identifies T cell proliferation-related genes (TRGs) impacting colorectal cancer (CRC) prognosis and treatment. A predictive signature based on TRGs helps stratify patients and guides therapeutic strategies for better CRC outcomes.

Area Of Science

  • Immunology
  • Oncology
  • Bioinformatics

Background

  • T cells are vital for antitumor immunity.
  • The role of T cell proliferation-related genes (TRGs) in colorectal cancer (CRC) prognosis and treatment response is not well understood.

Purpose Of The Study

  • To investigate the impact of TRGs on colorectal cancer (CRC) patient prognosis and therapeutic responses.
  • To develop a predictive signature for CRC based on TRGs.

Main Methods

  • Bioinformatic analysis of 33 TRGs and clinical data from multiple CRC patient datasets.
  • Consensus clustering to identify molecular subtypes and Lasso-Cox regression to build a predictive signature.
  • Tumor immune microenvironment analysis, biomarker screening, and in vitro/in vivo validation of therapeutic drugs.

Main Results

  • Two TRG clusters and three gene clusters were identified in CRC patients, correlating with survival, immune cells, and functions.
  • A validated predictive signature based on prognosis-associated DEGs was developed to assess patient risk.
  • Key TRGs (CDK1, BATF, IL1RN, ITM2A) were identified, and 7,8-benzoflavone demonstrated significant suppression of CRC cell proliferation and migration.

Conclusions

  • T cell proliferation-based molecular subtypes and predictive signatures can predict CRC patient outcomes, immune landscape, and treatment response.
  • Novel biomarker candidates and potential therapeutic agents, like 7,8-benzoflavone, were identified and validated for CRC treatment.

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