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  1. Home
  3. Predicting Outcomes Of Lung Cancer Using The Modified Glasgow Prognostic Score: A Systematic Review And Meta-analysis.
  1. Home
  3. Predicting Outcomes Of Lung Cancer Using The Modified Glasgow Prognostic Score: A Systematic Review And Meta-analysis.

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Predicting outcomes of Lung Cancer using the modified glasgow prognostic score: A systematic review and

Yonghua Min1, Xiaofeng Li2, Huafei Chen3

  • 1Yonghua Min, Department of Chest Disease Center, Zhejiang Rongjun Hospital, 309 Shuangyuan Road, Jiaxing, Zhejiang Province 314000, P.R. China.

Pakistan Journal of Medical Sciences
|February 15, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

The modified Glasgow Prognostic Score (mGPS) is linked to poorer survival outcomes in lung cancer patients. This score may serve as a valuable biomarker for predicting prognosis in lung cancer.

Keywords:
Lung cancerMeta-analysisPrognosisSystematic reviewSystemic inflammationmGPS

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Area of Science:

  • Oncology
  • Biomarkers
  • Clinical Prognosis

Background:

  • The modified Glasgow Prognostic Score (mGPS) has been proposed as a potential biomarker in lung cancer (LC).
  • The prognostic value of mGPS concerning overall survival (OS) and progression-free survival (PFS) in LC patients requires further clarification.

Purpose of the Study:

  • To investigate the correlation between the modified Glasgow Prognostic Score (mGPS) and overall survival (OS) or progression-free survival (PFS) in lung cancer patients.

Main Methods:

  • A systematic literature search was conducted across multiple databases (PubMed, Cochrane Library, EMbase, CINAHL, Trip Database, Worldwide Science, Google Scholar) for relevant studies published before May 30, 2021.
  • Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated to evaluate the association between mGPS and survival outcomes.

Main Results:

  • Analysis of 28 studies with 9,748 LC patients indicated that an elevated mGPS (≥ 0) was significantly associated with poorer OS (HR=1.54; 95% CI, 1.32-1.77) and PFS (HR=1.49; 95% CI, 1.17-1.82).
  • A significant correlation was found between mGPS scores of 1 or 2 and OS, but not PFS.
  • Subgroup analysis by ethnicity showed that mGPS ≥ 0 was linked to worse OS in both Asian and Caucasian lung cancer patient cohorts.

Conclusions:

  • Positive mGPS is demonstrably associated with adverse survival outcomes in lung cancer.
  • The modified Glasgow Prognostic Score (mGPS) shows potential as a prognostic biomarker for lung cancer patients.