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Published on: June 2, 2014
Study on the correlation between IL-12p70, IL-17A and migraine in children
Fan Yang1,2, Hai-Zhen Liu2, Jia-Ai Liu3
1Department of Pediatrics, Hebei Medical University, Shijiazhuang, China.
Insights
Elevated serum levels of interleukin-12p70 (IL-12p70) and interleukin-17A (IL-17A) may increase the risk of pediatric migraine. These cytokines show diagnostic and predictive value for childhood migraine.
Area of Science:
- Pediatric Neurology
- Immunology
- Biochemistry
Background:
- Migraine is a common neurological disorder in children, often presenting with complex symptoms.
- Understanding the underlying inflammatory mechanisms in pediatric migraine is crucial for diagnosis and treatment.
- Cytokines play a significant role in inflammatory processes and neurological conditions.
Purpose of the Study:
- To compare serum cytokine levels in children with migraine, encephalitis, and pneumonia.
- To identify specific cytokines associated with pediatric migraine.
- To explore the diagnostic and predictive value of these cytokines.
Main Methods:
- Serum cytokine levels were measured using immunofluorescence assay in 44 children with migraine, 27 with encephalitis, and 44 with pneumonia.
- Migraine group was subgrouped by age, gender, disease course, and coinfection.
- Statistical analysis, including correlation, was performed to compare cytokine levels.
Main Results:
- Serum levels of IL-4, TNF-α, IL-17A, and IL-12p70 were higher in the migraine group compared to the pneumonia group.
- IL-12p70 levels were also higher in the migraine group than in the encephalitis group.
- Elevated serum IL-12p70 and IL-17A were significantly associated with an increased risk of migraine in children.
Conclusions:
- Elevated serum IL-12p70 and IL-17A levels are potential risk factors for pediatric migraine.
- These cytokines may possess diagnostic and predictive value for childhood migraine.
- Further research is warranted to elucidate the precise role of these cytokines in migraine pathogenesis.
Objective:
To compare the serum levels of 12 cytokines in migraine group, encephalitis with headache symptoms group, pneumonia without headache symptoms group and migraine subgroups to explore the cytokines associated with migraine in children and their levels.
Methods:
A total of 44 children with migraine, 27 children in the encephalitis group with headache symptoms and 44 children in the pneumonia group without headache symptoms were selected from January 2022 to August 2023 in Hebei Children's Hospital. They were all tested for serum cytokines by immunofluorescence assay. The migraine group was further divided into subgroups according to different age, gender, course of disease, and presence of coinfection. The differences of serum cytokine levels among the above groups were compared, and the correlation analysis was carried out.
Results:
Except IL-5, there were no significant differences in the expression levels of other 11 inflammatory cytokines between migraine subgroups. Compared with encephalitis with headache symptoms group and pneumonia without headache symptoms group the serum levels of IL-4, TNF-α, IL-17A, and IL-12p70 were higher in migraine group than in pneumonia group, and the levels of IL-12p70 were higher than those in encephalitis group (p < 0.05). An increase in serum IL-12p70 (OR = 1.267, 95%CI 1.054-1.523, p = 0.012) and IL-17A (OR = 1.066, 95%CI 1.016-1.119, p = 0.010) levels had a significant effect on migraine.
Conclusion:
Elevated serum levels of IL-12p70 and IL-17A may increase the risk of migraine in children, which has certain diagnostic and predictive value.
