THE RELATIONSHIP BETWEEN TSH LEVELS, THYROID AUTOANTIBODIES AND ATHEROGENIC INDEX OF PLASMA, AST TO PLATELET RATIO...

Area of Science:

• Endocrinology
• Cardiovascular Medicine
• Hepatology

Background:

• Thyroid hormones play a key role in metabolism.
• Hypothyroidism is associated with an increased risk of atherosclerosis.
• Non-alcoholic fatty liver disease (NAFLD) shares metabolic risk factors with atherosclerosis.

Purpose of the Study:

• To evaluate the impact of hypothyroidism on Non-Alcoholic Fatty Liver Disease (NAFLD) and atherosclerosis.
• To assess the utility of Atherogenic Index of Plasma (AIP), AST to Platelet Ratio Index (APRI), and Fibrosis-4 (FIB-4) indices in hypothyroid patients.

Main Methods:

• Retrospective analysis of 1370 hypothyroid patients (excluding pregnant, thyroid cancer, cardiovascular, or liver disease history).
• Analysis of TSH, fT4, Anti-TPO, Anti-TG, platelet count, ALT, AST, HDL, and triglyceride levels.
• Calculation of AIP, APRI, and FIB-4 indices.

Main Results:

• AIP and FIB-4 indices showed age-related risk stratification.
• A positive correlation was found between APRI and FIB-4.
• AIP increased significantly with higher TSH levels in hypothyroid patients.

Conclusions:

• Atherogenic Index of Plasma (AIP) is strongly associated with TSH levels in hypothyroidism.
• Maintaining normal TSH levels through regular monitoring and treatment may mitigate atherosclerosis risk.
• Further research is needed to fully elucidate the complex interplay between hypothyroidism, NAFLD, and atherosclerosis markers.