Transporter Associated With Antigen Processing (TAP) 1 Gene Polymorphisms and Risks of Urothelial Cell Carcinoma Among the Japanese Population
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Certain gene variations in the transporter associated with antigen processing 1 (TAP1) gene increase the risk of urothelial cell carcinoma in Japanese females. Smoking did not correlate with these genetic risks.
Area Of Science
- Oncology
- Genetics
- Molecular Biology
Background
- Urothelial cell carcinoma (UCC) is a costly cancer due to high recurrence rates and treatment complications.
- Genetic factors, including gene polymorphisms, are implicated in UCC development.
- The transporter associated with antigen processing 1 (TAP1) gene plays a role in immune response and antigen presentation.
Purpose Of The Study
- To investigate the association between two single-nucleotide polymorphisms (SNPs) in the TAP1 gene and the risk of developing urothelial cell carcinoma.
- To analyze these genetic variations in the Japanese population.
Main Methods
- Genotyping of two TAP1 gene polymorphisms (I333V and D637G) using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP).
- Statistical analysis, including calculation of adjusted odds ratios (OR) with 95% confidence intervals (CI).
Main Results
- Females with mutant genotypes (A/G+G/G) for TAP1 I333V and D637G polymorphisms showed significantly increased odds of developing UCC (OR=2.28 and OR=2.50, respectively).
- A higher likelihood of UCC was observed in females with the (A/G+G/G) genotype compared to the A/A genotype.
- No significant correlation was found between smoking status and TAP1 gene polymorphisms in relation to UCC risk.
Conclusions
- TAP1 gene polymorphisms are associated with an increased risk of urothelial cell carcinoma in females.
- These findings highlight the role of specific genetic variations in UCC susceptibility, particularly in the female Japanese population.
- Further research may explore targeted genetic screening or therapeutic strategies based on these polymorphisms.
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
Related Concept Videos
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...