Values of serum neutrophil gelatinase-associated lipocalin and cystatin C after percutaneous coronary intervention...

Area of Science:

• Nephrology
• Cardiology
• Biomarker Discovery

Background:

• Serum creatinine (SCr) is an unreliable marker for early contrast-induced nephropathy (CIN) diagnosis.
• Percutaneous coronary intervention (PCI) procedures carry a risk of CIN, necessitating sensitive early detection methods.

Purpose of the Study:

• To evaluate the diagnostic value of serum neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C (Cys-C) for early CIN detection after PCI.
• To compare the sensitivity of NGAL and Cys-C with SCr in diagnosing CIN.

Main Methods:

• A study involving 300 patients undergoing PCI, divided into CIN (n=25) and non-CIN (n=275) groups.
• Measurement of SCr, Cys-C, and NGAL levels at various time points post-PCI.
• Evaluation of diagnostic sensitivity using receiver operating characteristic (ROC) curve analysis (Area Under the Curve - AUC).

Main Results:

• NGAL and Cys-C levels increased significantly in the CIN group at 6 and 12 hours post-operation, respectively (P<0.05).
• Both NGAL and Cys-C levels were significantly higher in the CIN group compared to the non-CIN group at 12, 24, and 48 hours post-operation (P<0.05).
• At 24 hours post-operation, the AUC values for NGAL, Cys-C, and SCr were 0.885, 0.874, and 0.856, respectively, indicating superior diagnostic performance for NGAL and Cys-C.

Conclusions:

• Serum NGAL and Cys-C levels effectively reflect early renal function changes post-PCI.
• NGAL and Cys-C are valuable biomarkers for the early diagnosis of contrast-induced nephropathy (CIN).