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Association between venous leg ulcers and chronic heart failure: A Mendelian randomization study
Changlan Ke1, Qiong Zhou2,3, Mei Lu4
1Shunde Hospital, Guangzhou University of Chinese Medicine, Foshan, China.
International Wound Journal
|February 15, 2024
Summary
This study found no causal link between chronic heart failure (CHF) and venous leg ulcers (VLU). Mendelian randomization analysis confirmed no bidirectional relationship, suggesting these conditions may not directly cause each other.
Area of Science:
- Cardiovascular Medicine
- Dermatology
- Genetics
Background:
- Observational studies suggest a potential association between chronic heart failure (CHF) and venous leg ulcers (VLU).
- The causal relationship between these two conditions remains unclear.
- Investigating causality is crucial for effective treatment and prevention strategies.
Purpose of the Study:
- To investigate the potential bidirectional causal relationship between chronic heart failure (CHF) and venous leg ulcers (VLU) using Mendelian randomization.
- To differentiate between association and causation in the VLU-CHF link.
Main Methods:
- Mendelian randomization (MR) analysis was performed using the 'TwoSampleMR' R package.
- Inverse variance weighted (IVW), weighted mode, MR-Egger, and weighted median methods were employed to assess the association.
- Genetic variants associated with VLU and CHF were used as instrumental variables.
Main Results:
- No statistically significant association was found between VLU and CHF using the IVW method (p = 0.6582).
- Consistent results were observed across weighted median (p = 0.7791), MR-Egger (p = 0.07296), and weighted mode (p = 0.6341) analyses.
- No evidence suggested that CHF increases the risk of developing VLU.
Conclusions:
- This study found no evidence of a bidirectional causal relationship between chronic heart failure (CHF) and venous leg ulcers (VLU).
- The findings suggest that the observed association may be due to confounding factors or other non-causal mechanisms.
- Further research is warranted to confirm these findings and explore alternative explanations for the VLU-CHF link.
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