Immunoinflammatory Response to Acute Noise Stress in Male Rats Adapted with Different Exercise Training

Area of Science:

• Physiology
• Exercise Science
• Environmental Health

Background:

• Noise pollution is a significant environmental stressor impacting physiological functions.
• Exercise interventions are explored for their potential to modulate stress responses.
• Understanding the effects of different exercise intensities on stress markers is crucial.

Purpose of the Study:

• To evaluate the impact of high-intensity interval training (HIIT) and moderate-intensity continuous training (MCT) on physiological responses to acute noise stress.
• To assess the effects of HIIT and MCT on corticosterone, interleukin-6 (IL-6), and monocyte levels in male rats under noise stress.

Main Methods:

• Forty-two male Wistar rats were assigned to control, training (HIIT, MCT), or stress groups (noise stress, HIIT+S, MCT+S).
• Exercise interventions (HIIT, MCT) were conducted for 8 weeks.
• Acute noise stress was applied, and blood samples were collected to measure corticosterone, IL-6, and monocyte counts.

Main Results:

• Both HIIT and MCT adaptations led to increased corticosterone and reduced monocytes compared to controls under noise stress.
• MCT increased basal corticosterone and IL-6, while HIIT+S showed higher corticosterone and lower monocytes post-stress.
• Training effects indicated higher corticosterone and monocytes in MCT compared to HIIT.

Conclusions:

• Previous exercise, particularly HIIT, intensified stress responses to noise in rats.
• Exercise did not augment inflammatory or innate immune responses to acute noise stress.
• HIIT and MCT differentially affect stress hormone and immune cell responses to noise pollution.