Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

94
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
94
Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

89
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
89
Cancer Survival Analysis01:21

Cancer Survival Analysis

346
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
346
Dialysis01:27

Dialysis

309
Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
309

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-term effects of testosterone therapy on prostate volume and LUTS in hypogonadal men: a retrospective study.

Scandinavian journal of urology·2026
Same author

Sex differences in health-related quality of life after renal cell carcinoma surgery: a population-based study in Sweden.

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation·2026
Same author

pVHL status in clear cell renal cell carcinoma regulates HIF-α and E-cadherin expression levels and their implications for tumor progression.

Upsala journal of medical sciences·2026
Same author

Real-world drivers of treatment choices in synchronous metastatic renal cell carcinoma.

BJUI compass·2026
Same author

Non-surgical management vs active treatment in T1a renal cell carcinoma: a population-based study.

BJU international·2025
Same author

Spectral and stiffness characterization of whole prostate gland to assist superficial cancer detection during radical prostatectomy.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2025

Related Experiment Video

Updated: Jul 3, 2025

Technical Modification of the Terminal Ureter During Total Transperitoneal Laparoscopic Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma
06:39

Technical Modification of the Terminal Ureter During Total Transperitoneal Laparoscopic Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma

Published on: November 22, 2019

7.7K

Multiple factors influence decision making for the surgical treatment in patients with renal cell carcinoma.

Britt-Inger Kröger Dahlin1, Jan Hlodan1, Ramin Ghaffarpour1

  • 1Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden.

Scandinavian Journal of Urology
|February 15, 2024
PubMed
Summary

Surgical strategy for renal cell carcinoma (RCC) depends on tumor size, T-stage, WHO performance status, and comorbidity index. Renal function was not an independent factor in treatment selection for RCC patients.

More Related Videos

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

13.6K
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

267

Related Experiment Videos

Last Updated: Jul 3, 2025

Technical Modification of the Terminal Ureter During Total Transperitoneal Laparoscopic Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma
06:39

Technical Modification of the Terminal Ureter During Total Transperitoneal Laparoscopic Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma

Published on: November 22, 2019

7.7K
A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

13.6K
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

267

Area of Science:

  • Urology
  • Nephrology
  • Oncology

Background:

  • Surgical strategy for renal cell carcinoma (RCC) is influenced by patient renal function.
  • Partial nephrectomy (PN) preserves kidney function better than radical nephrectomy (RN), reducing chronic kidney disease (CKD) risk.
  • This study evaluates the importance of renal function and other clinical variables in surgical treatment selection for RCC.

Purpose of the Study:

  • To determine the impact of renal function and clinical variables on surgical treatment selection for renal cell carcinoma (RCC).
  • To identify key factors influencing the choice between partial nephrectomy (PN) and radical nephrectomy (RN).

Main Methods:

  • Retrospective analysis of 663 RCC patients treated between 1994 and 2018.
  • Data collected included estimated glomerular filtration rate (eGFR), WHO performance status (WHO-PS), Charlson comorbidity index (CCI), tumor stage, size, and patient demographics.
  • Statistical analysis employed Mann-Whitney U, chi-squared tests, and logistic regression.

Main Results:

  • Of 663 patients, 455 underwent RN and 208 underwent PN.
  • Preoperative eGFR was higher in the PN group (80.8) compared to the RN group (77.1, p=0.015).
  • Logistic regression revealed tumor size, T-stage, WHO-PS, and CCI significantly influenced treatment selection; eGFR, M-stage, age, and gender did not.

Conclusions:

  • Tumor size, CCI, T-stage, and WHO-PS significantly impact surgical strategy for RCC.
  • In T1a RCC patients, tumor size and WHO-PS were independent predictors of treatment choice.
  • Adjusted analysis indicated that renal function did not independently associate with the treatment strategy in RCC patients.