Long-term prognostic value of thyroid hormones in left ventricular noncompaction

Area of Science:

• Cardiology
• Endocrinology
• Internal Medicine

Background:

• Thyroid function significantly impacts cardiovascular disease prognosis.
• Left ventricular noncompaction (LVNC) is a rare congenital heart defect associated with adverse cardiovascular events.

Purpose of the Study:

• To investigate the predictive value of thyroid hormones for adverse cardiovascular outcomes in patients with LVNC.
• To establish free triiodothyronine (FT3) as a potential prognostic biomarker in LVNC.

Main Methods:

• A longitudinal cohort study of 388 LVNC patients with complete thyroid function and cardiovascular assessments.
• Multivariable Cox regression and restricted cubic spline analyses were used to evaluate predictors.
• Patients were stratified by FT3 tertiles, and subgroup analyses were performed.

Main Results:

• Over 5.22 years, 25.3% experienced primary outcomes (cardiac death/transplant) and 33.5% had major adverse cardiovascular events (MACE).
• Low FT3 was independently associated with increased primary and secondary adverse cardiovascular outcomes.
• Lower FT3 levels correlated with severe cardiac dysfunction, remodeling, and higher mortality/MACE rates, especially in specific subgroups.

Conclusions:

• Low serum FT3 is an independent predictor of adverse cardiovascular outcomes in LVNC patients.
• Incorporating FT3 into risk scores can improve the prediction of MACE in LVNC.
• Thyroid hormone levels, particularly FT3, are critical for managing and predicting prognosis in LVNC.