Ti₃C₂/Ni/Sm-based electrochemical glucose sensor for sweat analysis using bipolar electrochemistry

Area of Science:

• Electrochemistry
• Materials Science
• Biosensing

Background:

• Electrochemical sensors are crucial for non-invasive analyte detection.
• Developing sensitive and selective glucose sensors for sweat analysis remains a challenge.
• Paper-based devices offer advantages in portability and cost-effectiveness for wearable sensors.

Purpose of the Study:

• To introduce an innovative electrochemical sensor for sweat glucose detection.
• To utilize bipolar electrochemistry on a paper substrate for enhanced sensing performance.
• To develop an enzyme-free glucose sensing platform with high sensitivity and accuracy.

Main Methods:

• Fabrication of a three-dimensional porous nanocomposite (MXene/NiSm-LDH) on a paper substrate.
• Utilizing bipolar electrochemistry for enzyme-free glucose oxidation.
• Employing potassium ferricyanide as a reporter molecule to generate a current signal proportional to glucose concentration.

Main Results:

• The sensor demonstrated exceptional electrocatalytic activity for glucose oxidation.
• Accurate sweat glucose determination was achieved in a linear range of 10 to 200 µM.
• A low limit of detection (LOD) of 3.6 µM (S/N=3) was obtained, indicating high sensitivity.
• Validation with real sweat samples showed promising and encouraging results.

Conclusions:

• The developed paper-based electrochemical sensor is effective for sensitive and accurate sweat glucose monitoring.
• The innovative use of bipolar electrochemistry and nanocomposite materials offers a promising approach for wearable biosensing.
• This enzyme-free platform holds potential for non-invasive glucose monitoring in various health-related applications.