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Exposure to Short- and Medium-Chain Chlorinated Paraffins and the Risk of Gestational Diabetes Mellitus: A Nested
Lina Yang1, Yu Yao1, Yujia Zeng1
1MOE Key Laboratory of Environmental Remediation and Ecosystem Health, Institute of Environmental Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China.
Environmental Science & Technology
|February 15, 2024
Summary
Exposure to chlorinated paraffins (CPs) during pregnancy is linked to a higher risk of gestational diabetes mellitus (GDM). Higher levels of short- and medium-chain CPs in maternal serum correlate with increased GDM incidence and disturbed glucose homeostasis.
Area of Science:
- Environmental Health
- Endocrinology
- Toxicology
Background:
- Chlorinated paraffins (CPs) are industrial chemicals with known toxicological effects on metabolism.
- Limited data exists on human exposure to CPs and their impact on gestational diabetes mellitus (GDM).
Purpose of the Study:
- To investigate the association between maternal serum concentrations of short-chain (SCCPs) and medium-chain (MCCPs) chlorinated paraffins and the risk of GDM.
- To explore the impact of CP exposure on maternal glucose homeostasis.
Main Methods:
- Prospective study with a nested case-control design involving 102 GDM cases and 204 controls.
- Serum samples analyzed for SCCP and MCCP concentrations using established methods.
- Statistical analyses, including logistic regression and weighted quantile sum regression, were employed.
Main Results:
- Significantly higher median concentrations of SCCPs and MCCPs were observed in pregnant women with GDM compared to controls (p < 0.01).
- Elevated SCCP and MCCP levels were associated with increased GDM risk, with odds ratios of 7.07 and 3.34 for the highest quartiles, respectively.
- MCCPs showed an inverted U-shaped association with GDM risk, and specific congeners (C13H23Cl5, C10H16Cl6) were identified as key drivers of GDM risk.
Conclusions:
- Maternal serum CP concentrations are significantly associated with an increased risk of GDM.
- Exposure to SCCPs and MCCPs may disrupt maternal glucose homeostasis during pregnancy.
- Findings highlight the potential role of environmental contaminants like CPs in GDM pathogenesis and inform public health risk assessment.
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