TR(i)P Goes On: Auxiliary TRP Channel Subunits?

Area of Science:

• Physiology
• Molecular Biology
• Biophysics

Background:

• Transient receptor potential (TRP) channels are vital cellular sensors and effectors.
• Their significance in sensory perception was highlighted by a Nobel Prize.
• This review focuses on molecular architecture rather than a comprehensive overview.

Purpose of the Study:

• To summarize the molecular architecture of native TRP channel/protein complexes in vivo.
• To use canonical TRP channels as an example to illustrate this architecture.
• To provide a basis for understanding native TRP currents and their modulation.

Main Methods:

• Review of existing literature on TRP channel nomenclature and structure.
• Focus on in vivo molecular architecture of TRP channel complexes.
• Analysis of canonical TRP channel subfamily as a model.

Main Results:

• Detailed summary of TRP channel molecular architecture in native complexes.
• Explanation of how architecture underlies native TRP current signatures.
• Insights into the control of these currents by endogenous modulators and drugs.

Conclusions:

• The molecular architecture of TRP channels dictates their function and modulation.
• Understanding this architecture is key to comprehending TRP channel activity in vivo.
• This provides a foundation for exploring therapeutic interventions targeting TRP channels.