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Updated: Jul 3, 2025

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo
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High-contrast handheld FFOCT system for tissue imaging.

Yifeng Tang, Wanrong Gao

    Optics Letters
    |February 15, 2024
    PubMed
    Summary
    This summary is machine-generated.

    We developed a novel full-field optical coherence tomography (FFOCT) system using fiber optics. This advanced imaging system enhances detection sensitivity and suppresses artifacts for clearer microstructure visualization.

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    Area of Science:

    • Biomedical Optics
    • Optical Imaging
    • Microscopy

    Background:

    • Low contrast limits imaging of subsurface microstructures in biological samples.
    • Conventional optical coherence tomography systems face challenges with sensitivity and artifact reduction.

    Purpose of the Study:

    • To introduce a novel full-field optical coherence tomography (FFOCT) system.
    • To improve detection sensitivity and image quality for subsurface microstructure imaging.

    Main Methods:

    • A new FFOCT system utilizing a fiber bundle and multimode optical fiber probe.
    • Integration of Michelson and Fizeau interferometers in a tandem structure.
    • Application of spatial filtering in the Fourier domain and inverse filtering to mitigate artifacts.

    Main Results:

    • The system demonstrates enhanced detection sensitivity due to single light propagation through the fiber bundle.
    • Pixelation artifacts and multiple scattering effects in en face images are significantly suppressed.
    • Successful acquisition of depth-resolved en face images of human finger skin and porcine esophagus ex vivo.

    Conclusions:

    • The developed FFOCT system offers improved sensitivity and image quality for biological sample imaging.
    • The system effectively overcomes limitations of low contrast and artifacts in subsurface microstructure visualization.
    • Demonstrated capability for imaging complex biological tissues ex vivo.