Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Inflammatory changes reflected in middle ear effusion in otitis media.

S K Juhn, T T Jung

    Auris, Nasus, Larynx
    |January 1, 1985
    PubMed
    Summary

    Analyzing middle ear effusion (MEE) in otitis media (OM) offers insights into disease causes and inflammation. Biochemical and cellular markers in MEE reflect changes in the middle ear mucosa during OM.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Blood-labyrinth barrier and fluid dynamics of the inner ear.

    The international tinnitus journal·2003
    Same author

    Determination of ototoxicity of common otic drops using isolated cochlear outer hair cells.

    The Laryngoscope·2002
    Same author

    Effect of inhibitor of tumor necrosis factor-alpha on experimental otitis media with effusion.

    The Annals of otology, rhinology, and laryngology·2001
    Same author

    Concentration of nitric oxide metabolites in middle ear effusion.

    International journal of pediatric otorhinolaryngology·2001
    Same author

    Effect of tumor necrosis factor-alpha on experimental otitis media with effusion.

    The Laryngoscope·2001
    Same author

    Effects of common topical otic preparations on the morphology of isolated cochlear outer hair cells.

    Acta oto-laryngologica·2001

    Area of Science:

    • Otolaryngology
    • Pathology
    • Biochemistry

    Background:

    • Otitis media (OM) is a prevalent condition characterized by middle ear effusion (MEE).
    • Understanding MEE composition is crucial for diagnosing OM etiology and inflammation severity.
    • Eustachian tube dysfunction and infections are key factors in OM development.

    Purpose of the Study:

    • To investigate the biochemical, cytological, and immunochemical characteristics of MEE in otitis media.
    • To correlate MEE findings with inflammatory changes in the middle ear mucosa (MEM) and subepithelial space (SES).

    Main Methods:

    • Analysis of middle ear effusion (MEE) using biochemical, cytological, and immunochemical markers.
    • Examination of middle ear mucosa (MEM) and subepithelial space (SES) in human and animal studies of otitis media (OM).

    Main Results:

    • Biochemical changes in MEE are linked to vasodilation, increased vascular permeability, and inflammatory cell activity.
    • The subepithelial space (SES) shows significant cellular-immune responses in OM, including fibroblast proliferation and immune cell infiltration.
    • Analysis of markers like prostaglandins and immunoglobulins in MEE indicates inflammatory processes in the MEM.

    Conclusions:

    • MEE analysis provides valuable diagnostic information for otitis media.
    • Inflammatory components from MEM and MEE significantly influence the clinical progression of OM.
    • The subepithelial space plays a critical role in the pathogenesis of various otitis media types.

    Related Experiment Videos