Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

334
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
334
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

145
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
145
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

450
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
450
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

127
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
127

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeting the kidney-gut axis in chronic kidney disease: From biological insight to therapeutic opportunity.

European journal of internal medicine·2026
Same author

Innovative diagnostic techniques and their clinical implications in food allergy: current clinical practice and future perspectives.

Frontiers in allergy·2026
Same author

Dupilumab for Eosinophilic Esophagitis in Adolescents and Adults: Real-World Outcomes Across Different Dosing Regimens from the EoE CONNECT Registry.

The American journal of gastroenterology·2026
Same author

Any role for respiratory allergens in IBS symptoms? From pathogenetic hypothesis to therapeutic implications.

Frontiers in allergy·2026
Same author

Allergen Immunotherapy for the Treatment of Eosinophilic Esophagitis. An EAACI Task Force Systematic Review.

Clinical and translational allergy·2026
Same author

Disease clearance in immune-mediated gastrointestinal disorders: A new standard or a semantic trap?

European journal of internal medicine·2026

Related Experiment Video

Updated: Jul 3, 2025

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

7.1K

Recent advances in intestinal fibrosis.

Marco Vincenzo Lenti1, Giovanni Santacroce1, Giacomo Broglio1

  • 1Department of Internal Medicine and Medical Therapeutics, University of Pavia, First Department of Internal Medicine, San Matteo Hospital Foundation, Pavia, Italy.

Molecular Aspects of Medicine
|February 15, 2024
PubMed
Summary

Inflammatory bowel disease fibrosis, or fibrogenesis, is common despite new treatments. Controlling gut inflammation is key to preventing bowel strictures and the need for surgery.

Keywords:
CollagenCrohn's diseaseExtracellular matrixMyofibroblastStrictureplastyUlcerative colitis

More Related Videos

Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin
10:21

Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin

Published on: September 12, 2019

7.2K
Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation
07:05

Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation

Published on: December 15, 2017

8.3K

Related Experiment Videos

Last Updated: Jul 3, 2025

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

7.1K
Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin
10:21

Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin

Published on: September 12, 2019

7.2K
Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation
07:05

Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation

Published on: December 15, 2017

8.3K

Area of Science:

  • Gastroenterology
  • Immunology
  • Pathology

Background:

  • Inflammatory bowel disease (IBD) treatments have advanced, yet tissue fibrosis remains a common complication.
  • Excessive extracellular matrix deposition in the bowel wall leads to strictures, often requiring surgical intervention.
  • While fibrogenesis is a natural response to chronic inflammation, its dysregulation in IBD is detrimental.

Purpose of the Study:

  • To review the current understanding of mechanisms driving gut fibrogenesis in IBD.
  • To discuss diagnostic approaches for identifying bowel fibrosis.
  • To explore potential therapeutic targets for anti-fibrotic strategies in IBD.

Main Methods:

  • Literature review of mechanisms, diagnosis, and therapeutic targets for IBD-associated fibrosis.
  • Synthesis of current knowledge on key cellular and molecular players in fibrogenesis.
  • Analysis of the link between inflammation control and fibrosis prevention.

Main Results:

  • Persistent mucosal inflammation is the primary driver of a pro-fibrogenic environment in IBD.
  • Myofibroblasts, fibroblasts, immune cells, growth factors, and cytokines are key mediators of fibrosis.
  • Currently, no direct anti-fibrotic therapies exist; inflammation control is the main preventive strategy.

Conclusions:

  • Understanding IBD fibrogenesis mechanisms is crucial for developing targeted therapies.
  • Early diagnosis and management of inflammation are essential to prevent fibrotic complications.
  • Identifying druggable targets offers future hope for managing IBD-associated bowel fibrosis.