Academic drug discovery: Challenges and opportunities

Area of Science:

• Drug Discovery
• Academic Research
• Pharmaceutical Development

Background:

• Academic drug discovery often mirrors industrial models, focusing on novel targets and screening.
• Existing approaches may not fully leverage the diverse capabilities of academic stakeholders.
• There is a need for more efficient and collaborative drug discovery frameworks in academia.

Purpose of the Study:

• To describe a novel academic drug discovery model.
• To highlight the efficient utilization of stakeholder capabilities and resources.
• To present a portfolio-based, investment-ready approach to academic drug discovery.

Main Methods:

• Development of a large portfolio of drug discovery projects.
• Inclusion of targeted 'derisking' work to ensure project investment readiness.
• Analysis of the model's advantages and limitations.

Main Results:

• The described model facilitates efficient resource allocation among stakeholders.
• A portfolio of derisked, investment-ready drug projects has been established.
• The approach offers potential benefits for other academic institutions and consortia.

Conclusions:

• The presented drug discovery model offers a more efficient alternative for academic settings.
• This approach can enhance collaboration and resource utilization in academic drug discovery.
• The model's principles and outcomes are relevant for broader academic and consortium-based research endeavors.