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Determination of Risk Factors for Acute Kidney Injury In Orthotopic Cardiac Transplantation
Deniz Sarp Beyazpinar1, Adem İlkay Diken2, İzzet Hafez2
1Cardiovascular Surgery Department, Başkent University Ankara Hospital, Ankara, Turkey.
Transplantation Proceedings
|February 15, 2024
Summary
Acute kidney injury (AKI) is common after cardiac transplantation. Risk factors include older age, hypertension, higher body surface area, and elevated preoperative creatinine, which may help reduce patient mortality.
Area of Science:
- Nephrology
- Cardiology
- Transplantation Medicine
Background:
- Acute kidney injury (AKI) is a significant complication following orthotopic cardiac transplantation.
- Identifying risk factors for AKI is crucial for improving patient outcomes.
Purpose of the Study:
- To determine the risk factors associated with the development of acute kidney injury in patients undergoing orthotopic cardiac transplantation.
Main Methods:
- Retrospective review of 102 cardiac transplantation patients between February 2003 and December 2022.
- Data collected included demographics, comorbidities, preoperative parameters, blood tests, intraoperative variables, and AKI development.
- Assessment of AKI stage and need for renal replacement therapy.
Main Results:
- 54% of patients developed AKI, with 31% requiring renal replacement therapy.
- AKI group (AKI+) was older, had higher body surface area, and a higher prevalence of ex-smokers and hypertension.
- AKI+ group had higher preoperative serum creatinine and lower intraoperative urine output compared to the non-AKI group.
Conclusions:
- Acute kidney injury is a frequent complication post-cardiac transplantation.
- Identified risk factors for AKI include older age, higher body surface area, history of hypertension, ex-smoker status, elevated preoperative serum creatinine, and low intraoperative urine output.
- Reducing AKI incidence may decrease mortality and morbidity associated with cardiac transplantation.
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