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  1. Home
  3. The Association Of E2f1 And E2f2 Single Nucleotide Polymorphisms With Laryngeal Squamous Cell Carcinoma Pathomorphological Features.
  1. Home
  3. The Association Of E2f1 And E2f2 Single Nucleotide Polymorphisms With Laryngeal Squamous Cell Carcinoma Pathomorphological Features.

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The association of E2F1 and E2F2 single nucleotide polymorphisms with laryngeal squamous cell carcinoma

Tomas Jakstas1, Agne Bartnykaite2, Evaldas Padervinskis3

  • 1Department of Otorhinolaryngology, Lithuanian University of Health Sciences, Kaunas, Lithuania. tomas.jakstas@lsmu.lt.

BMC Cancer
|February 15, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Specific gene variants in E2F2 and E2F1 impact laryngeal squamous cell carcinoma (LSCC) aggressiveness, affecting tumor differentiation and lymph node involvement, but not overall survival.

Keywords:
E2F1E2F2Laryngeal squamous cell carcinomaSNP

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Area of Science:

  • Genetics
  • Oncology
  • Molecular Biology

Background:

  • Laryngeal squamous cell carcinoma (LSCC) presents a high mortality rate and poor prognosis in advanced stages.
  • Identifying specific prognostic blood-based markers for LSCC is crucial for improved patient outcomes.
  • This study investigates the role of single nucleotide polymorphisms (SNPs) in LSCC development and progression.

Purpose of the Study:

  • To evaluate the impact of four SNPs in E2F1 and E2F2 genes on LSCC development.
  • To assess the association between these SNPs and LSCC morphological features.
  • To determine the correlation of these SNPs with patient 5-year survival rates.

Main Methods:

  • Genotyping of 200 LSCC patients and 200 controls using RT-PCR.
  • Analysis of four SNPs: E2F1 (rs3213183, rs3213180) and E2F2 (rs2075993, rs3820028).
  • Evaluation of associations with LSCC risk, clinical manifestations, and 5-year survival.

    • Main Results:

    • No direct association was found between the analyzed SNPs and LSCC development.
    • E2F2 rs2075993 G allele and rs3820028 A allele carriers showed a significantly higher risk for poorly differentiated LSCC.
    • E2F1 rs3213180 GC heterozygotes had an increased risk for lymph node involvement.

    Conclusions:

    • The E2F2 gene variants rs2075993 and rs3820028 are associated with LSCC differentiation.
    • The E2F1 gene variant rs3213180 is linked to lymph node involvement in LSCC.
    • No significant association was observed between the studied SNPs and the 5-year survival rate of LSCC patients.