Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Experimental endocarditis and fosfomycin.

A Rodríguez, M V Vicente, T Olay

    Drugs Under Experimental and Clinical Research
    |January 1, 1985
    PubMed
    Summary

    Fosfomycin combined with other antibiotics showed synergistic effectiveness against bacterial endocarditis in rabbits. These combinations significantly reduced bacterial growth compared to single antibiotic treatments.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Histopathologic prognostic score in colorectal adenocarcinomas.

    Anticancer research·1998
    Same author

    Earlier onset of Alzheimer's disease in men with Down syndrome.

    Neurology·1998
    Same author

    Molecular prophets of death in the fly.

    American journal of human genetics·1998
    Same author

    Is the high level of nitric oxide metabolites a marker in early rejection after experimental islet pancreas transplantation?

    Transplantation proceedings·1998
    Same author

    Structure of the human CD94 C-type lectin gene.

    Immunogenetics·1998
    Same author

    Risk factors, treatment, and outcome of central nervous system recurrence in adults with intermediate-grade and immunoblastic lymphoma.

    Blood·1998

    Area of Science:

    • Microbiology
    • Pharmacology
    • Infectious Diseases

    Background:

    • Bacterial endocarditis remains a significant clinical challenge.
    • Identifying effective antibiotic combinations is crucial for treatment.
    • Fosfomycin is an antibiotic with broad-spectrum activity.

    Purpose of the Study:

    • To evaluate the in vitro and in vivo effectiveness of fosfomycin in combination with other antibiotics.
    • To assess the synergistic potential of fosfomycin-based regimens against key endocarditis-causing bacteria.

    Main Methods:

    • In vitro susceptibility testing of bacterial strains (S. sanguis, S. faecalis, S. aureus, P. aeruginosa) against fosfomycin combinations.
    • In vivo study using a rabbit model of left-sided endocarditis.
    • Quantification of bacterial colony-forming units per gram (CFU/g) in vegetations.

    Main Results:

    • In vitro synergistic activity was observed for fosfomycin combined with penicillin, cloxacillin, and amikacin.
    • In vivo studies demonstrated significant synergism, with combination therapies yielding greater reductions in vegetation bacterial load.
    • Fosfomycin combinations outperformed monotherapy in reducing bacterial burden in the endocarditis model.

    Conclusions:

    • Fosfomycin in combination with penicillin, cloxacillin, or amikacin exhibits synergistic efficacy against common endocarditis pathogens.
    • These findings support the potential of fosfomycin-based combination therapies for treating bacterial endocarditis.
    • Further clinical investigation is warranted to translate these promising preclinical results.

    Related Experiment Videos