Related Experiment Videos
Cardiotoxic effects of adriamycin and mitochondrial oxidation in rat cardiac tissue
Drugs Under Experimental and Clinical Research
|January 1, 1985
Abstract:
Rats were subjected to chronic treatment with adriamycin (ADR). Significant alterations of ECG tracings were induced, starting from the third week of treatment. These alterations were related to mitochondrial damage of the heart tissue. A decrease of respiration rate in phosphorylating conditions was observed in isolated organelles over a period of three weeks. Meanwhile, adriamycinol (ADRol) concentration in heart extracts increased during chronic treatment.