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Association Between the Risk of Multiple Sclerosis and Dietary Proinflammatory/Anti-Inflammatory Food Intake and

Alireza Hatami1, Maryam Ahmadi-Khorram1, Fatemeh Keykhaei1

  • 1Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad 91779-48564, Iran.

Clinical Nutrition Research
|February 16, 2024
PubMed

Insights

A diet high in inflammatory foods increases multiple sclerosis (MS) risk. The pro-inflammatory/anti-inflammatory food intake score (PAIFIS) can predict MS, highlighting diet

Area of Science:

  • Nutrition Science
  • Neurology
  • Epidemiology

Background:

  • Inflammation and pro-inflammatory diets are potential risk factors for multiple sclerosis (MS).
  • Understanding dietary impacts on MS risk is crucial for prevention and management strategies.

Purpose of the Study:

  • To investigate the association between dietary inflammatory potential and MS risk.
  • To evaluate the role of dietary diversity in MS development.

Main Methods:

  • A hospital-based case-control study involving 197 MS patients and 200 healthy controls.
  • Assessment of dietary intake using a 160-item semiquantitative food frequency questionnaire.
  • Calculation of pro-inflammatory/anti-inflammatory food intake score (PAIFIS) and dietary diversity score (DDS).

Main Results:

  • The PAIFIS was significantly higher in MS patients compared to healthy individuals (p = 0.001).
  • A higher PAIFIS was significantly associated with an increased risk of MS (odds ratio, 1.002; 95% CI, 1.001-1.004; p = 0.001).
  • Dietary diversity score (DDS) did not show a significant association with MS risk in this study.

Conclusions:

  • The PAIFIS, reflecting dietary inflammation, may serve as a predictive index for multiple sclerosis risk.
  • Dietary inflammatory potential is a significant factor associated with MS.
  • Further research is warranted to confirm these findings and explore clinical implications.
Keywords:
Diet recordsMicronutrientsMultiple sclerosis

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