Related Experiment Video
Updated: Jul 2, 2026
Construction and Characterization of a Novel Vocal Fold Bioreactor
Published on: August 1, 2014
Effect of amniotic membrane/collagen scaffolds on laryngeal cartilage repair
Kamyar Iravani1, Simin Mousavi1, Seyed Mohammad Owji2
1Otolaryngology Research Center, Department of Otolaryngology Shiraz University of Medical Sciences Shiraz Iran.
Objectives:
Laryngeal cartilage defects are a major problem that greatly impacts structural integrity and function. Cartilage repair is also a challenging issue. This study evaluated the efficacy of a collagen scaffold enveloped by amniotic membrane (AM/C) on laryngeal cartilage repair.
Study Design:
Experimental animal study.
Methods:
Fourteen Dutch rabbits were enrolled in the study. A 5 mm cartilage defect was created in the right and left thyroid lamina. The animals were divided into two groups randomly. Group 1 collagen scaffolds and group 2 AM/C were applied to the right side defects. Left side defects were not repaired, serving as control. Histologic evaluation was done 45 and 90 days following collagen and AM/C application with criteria of tissue and cell morphology, lacuna formation, vascularization, and inflammation.
Results:
Significant improvement in cartilage repair was observed in the AM/C side compared to the control side in all histologic criteria after 45 days (p<.05). After 90 days, cartilage repair improved in cell morphology, lacuna formation, and inflammation significantly (p<.05).
Conclusion:
The combination of amniotic membrane and collagen scaffolds provides a promising treatment modality for improving the repair of laryngeal cartilage defects.
Level Of Evidence:
NA.
Related Concept Videos
01:27Fractures: Bone Repair
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
01:31Bone Remodeling and Repair